RT Journal Article
T1 The nutrigenetic influence of the interaction between dietary vitamin E and TXN and COMT gene polymorphisms on waist circumference: a case control study.
A1 Mansego, Maria L
A1 De Marco, Griselda
A1 Ivorra, Carmen
A1 Lopez-Izquierdo, Raúl
A1 Morcillo, Sonsoles
A1 Rojo-Martínez, Gemma
A1 González-Albert, Verónica
A1 Martinez, Fernando
A1 Soriguer, Federico
A1 Martín-Escudero, Juan C
A1 Redon, Josep
A1 Chaves, F Javier
K1 Vitamin E intake
K1 Oxidative stress
K1 Polimorphism
K1 Waist circumference
K1 Abdominal obesity
K1 Thioredoxin
K1 Catechol-O-methyltransferase
K1 Antioxidantes
K1 Dieta
K1 Genes informadores
K1 Genotipo
K1 Nutrigenómica
K1 Obesidad abdominal
K1 Factores de riesgo
K1 Vitamina E
K1 Perímetro abdominal
AB BACKGROUNDAbdominal obesity (AO) is a common modifiable risk factor for certain non-communicable diseases associated with enhanced oxidative stress (OS). The objective of this work was to investigate whether the interaction between antioxidant vitamin intake and OS-related polymorphisms modulates gene-associated anthropometry in a Spanish population.METHODSA total of 246 subjects with AO, and 492 age and gender matched non-AO subjects were included in the study. Anthropometric, biochemical, and OS parameters, and antioxidant dietary intake data were assessed using validated procedures. DNA from white blood cells was isolated and the genotype of seven polymorphisms from genes involved in OS (pro-oxidant and antioxidant) were analyzed using the SNPlex system. The effects of the c.-793T > C polymorphism on promoter activity and thus thioredoxin (TXN) activity were examined using reporter assays.RESULTSThe AO group had higher 8-Oxo-2'-deoxyguanosine levels and took in less vitamin A and vitamin E compared to the non-AO group. Logistic regression analysis revealed that the rs2301241 polymorphism in TXN and rs740603 in catechol-O-methyltransferase (COMT) were associated with waist circumference (WC) and AO. Moreover, these polymorphisms were more strongly associated with variations in WC in subjects with low vitamin E intakes. A promoter assay revealed that the T to C conversion at c.-793 (rs2301241) induced a more than two fold increase in reporter gene expression.CONCLUSIONSWC is associated both with dietary vitamin E intake and genetic variants of TXN and COMT suggesting that existence of a complex nutrigenetic pathway that involves regulation of AO.
PB BioMed Central
YR 2015
FD 2015-09-02
LK http://hdl.handle.net/10668/2326
UL http://hdl.handle.net/10668/2326
LA en
NO Mansego ML, De Marco G, Ivorra C, Lopez-Izquierdo R, Morcillo S, Rojo-Martínez G, et al. The nutrigenetic influence of the interaction between dietary vitamin E and TXN and COMT gene polymorphisms on waist circumference: a case control study. J Transl Med. 2015; 13:286
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 20, 2025