TY - JOUR AU - Tabah, Alexis AU - Cotta, Menino Osbert AU - Garnacho-Montero, Jose AU - Schouten, Jeroen AU - Roberts, Jason A AU - Lipman, Jeffrey AU - Tacey, Mark AU - Timsit, Jean-François AU - Leone, Marc AU - Zahar, Jean Ralph AU - De-Waele, Jan J PY - 2015 DO - 10.1093/cid/civ1199 UR - http://hdl.handle.net/10668/9680 T2 - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AB - Antimicrobial de-escalation (ADE) is a strategy to reduce the spectrum of antimicrobials and aims to prevent the emergence of bacterial resistance. We present a systematic review describing the definitions, determinants and outcomes associated with... LA - en KW - de-escalation KW - resistance KW - stewardship KW - streamlining KW - Anti-Bacterial Agents KW - Bacterial Infections KW - Clinical Trials as Topic KW - Cohort Studies KW - Cross Infection KW - Drug Resistance, Microbial KW - Humans KW - Intensive Care Units KW - Severity of Illness Index KW - Treatment Outcome TI - A Systematic Review of the Definitions, Determinants, and Clinical Outcomes of Antimicrobial De-escalation in the Intensive Care Unit. TY - research article VL - 62 ER -