RT Journal Article
T1 Impact of Intensive Lifestyle Modification on Levels of Adipokines and Inflammatory Biomarkers in Metabolically Healthy Obese Women.
A1 Gomez-Huelgas, Ricardo
A1 Ruiz-Nava, Josefina
A1 Santamaria-Fernandez, Sonia
A1 Vargas-Candela, Antonio
A1 Alarcon-Martin, Ana Victoria
A1 Tinahones, Francisco J
A1 Bernal-Lopez, M Rosa
K1 Adipokines
K1 Biomarkers
K1 Body Weight
K1 Diet, Mediterranean
AB For the metabolically healthy obese (MHO) subjects, it is unclear whether weight loss provides cardiometabolic benefits. Our objective was to evaluate whether changes in adipokine and inflammatory biomarker levels were related to lifestyle modification (with Mediterranean diet and physical exercise program). 115 women (35-55 years) with BMI of 30-40 kg/m2 and ≤1 metabolic syndrome criteria were included. After a 2-year intervention, participants were classified by percent weight loss: Group 1,  The final sample comprised 67 women. 23 (38.3%) lost  Weight loss reduces inflammatory biomarkers in the MHO but induces a deterioration in the adipokine profile, which does not improve with diet and exercise intervention. These findings allow us to clarify mechanisms behind inflammation and metabolic disorder genesis so as to prevent development of obesity-associated comorbidities.
PB Wiley
YR 2019
FD 2019-04-09
LK http://hdl.handle.net/10668/13970
UL http://hdl.handle.net/10668/13970
LA en
NO Gomez-Huelgas R, Ruiz-Nava J, Santamaria-Fernandez S, Vargas-Candela A, Alarcon-Martin AV, Tinahones FJ, et al. Impact of Intensive Lifestyle Modification on Levels of Adipokines and Inflammatory Biomarkers in Metabolically Healthy Obese Women. Mediators Inflamm. 2019 Apr 9;2019:4165260
NO This work was supported by grants from the Instituto de Salud Carlos III, cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER (PI12/01373 and “Centros de Investigación En Red” (CIBER, CB06/03/0018)), and M. Rosa BernalLopez was supported by the “Miguel Servet Type I” program (CP15/00028) from the ISCIII-Madrid (Spain), cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER.
DS RISalud
RD Apr 10, 2025