RT Journal Article
T1 Torsional wave elastography to assess the mechanical properties of the cornea.
A1 Torres, Jorge
A1 H Faris, Inas
A1 Callejas, Antonio
A1 Reyes-Ortega, Felisa
A1 Melchor, Juan
A1 Gonzalez-Andrades, Miguel
A1 Rus, Guillermo
K1 Swine
K1 Tonometry, ocular
K1 Viscosity
AB Corneal mechanical changes are believed to occur before any visible structural alterations observed during routine clinical evaluation. This study proposed developing an elastography technique based on torsional waves (TWE) adapted to the specificities of the cornea. By measuring the displacements in the propagation plane perpendicular to the axis of the emitter, the effect of guided waves in plate-like media was proven negligible. Ex vivo experiments were carried out on porcine corneal samples considering a group of control and one group of alkali burn treatment ([Formula: see text]OH) that modified the mechanical properties. Phase speed was recovered as a function of intraocular pressure (IOP), and a Kelvin-Voigt rheological model was fitted to the dispersion curves to estimate viscoelastic parameters. A comparison with uniaxial tensile testing with thin-walled assumptions was also performed. Both shear elasticity and viscosity correlated positively with IOP, being the elasticity lower and the viscosity higher for the treated group. The viscoelastic parameters ranged from 21.33 to 63.17 kPa, and from 2.82 to 5.30 Pa s, for shear elasticity and viscosity, respectively. As far as the authors know, no other investigations have studied this mechanical plane under low strain ratios, typical of dynamic elastography in corneal tissue. TWE reflected mechanical properties changes after treatment, showing a high potential for clinical diagnosis due to its rapid performance time and paving the way for future in vivo studies.
PB Nature Publishing Group
YR 2022
FD 2022-05-05
LK http://hdl.handle.net/10668/19607
UL http://hdl.handle.net/10668/19607
LA en
NO Torres J, H Faris I, Callejas A, Reyes-Ortega F, Melchor J, Gonzalez-Andrades M, et al. Torsional wave elastography to assess the mechanical properties of the cornea. Sci Rep. 2022 May 19;12(1):8354
NO Tis research was funded by Ministerio de Educación, Cultura y Deporte Grant Numbers DPI2017-83859-R, DPI2014-51870-R, UNGR15-CE-3664 and EQC2018-004508-P; Ministerio de Sanidad, Servicios Sociales e Igualdad Grant Numbers DTS15/00093 and PI16/00339; Instituto de Salud Carlos III y Fondos Feder; Junta de Andalucía Grant Numbers PI-0107-2017, PIN-0030-2017 and IE2017-5537; MCIN/AEI /10.13039/501100011033 grant number PRE2018-086085 (Co-funded by European Social Fund “Investing in your future”); Consejería de economía, conocimiento, empresas y universidad and European Regional Development Fund (ERDF) SOMM17/6109/UGR, B-TEP-026- IE2017-5537 and P18-RT-1653.
DS RISalud
RD Apr 6, 2025