RT Journal Article
T1 Salvage radiosurgery for selected patients with recurrent malignant gliomas.
A1 Martínez-Carrillo, Miguel
A1 Tovar-Martín, Isabel
A1 Zurita-Herrera, Mercedes
A1 Moral-Ávila, Rosario Del
A1 Guerrero-Tejada, Rosario
A1 Saura-Rojas, Enrique
A1 Osorio-Ceballos, Juan Luis
A1 Arrebola-Moreno, Juan Pedro
A1 Expósito-Hernández, José
K1 Neoplasias Encefálicas
K1 Estudios de Seguimiento
K1 Astrocitoma
K1 Humanos
K1 Radiocirugia
K1 Terapia Recuperativa
K1 Resultado del Tratamiento
K1 Estado de Ejecución de Karnofsky
K1 Procedimientos Quirúrgicos Mínimamente Invasivos
AB Purpose. To analyse the survival after salvage radiosurgery and to identify prognostic factors. Methods. We retrospectively reviewed 87 consecutive patients, with recurrent high-grade glioma, that underwent stereotactic radiosurgery between 1997 and 2010. We evaluated the survival after initial diagnosis and after reirradiation. The prognostic factors were analysed by bivariate and multivariate Cox regression model. Results. The median age was 48 years old. The primary histology included anaplastic astrocytoma (47%) and glioblastoma (53%). A margin dose of 18 Gy was administered in the majority of cases (74%). The median survival after initial diagnosis was 21 months (39 months for anaplastic astrocytoma and 18.5 months for glioblastoma) and after reirradiation it was 10 months (17 months for anaplastic astrocytoma and 7.5 months for glioblastoma). In the bivariate analyses, the prognostic factors significantly associated with survival after reirradiation were age, tumour and treatment volume at recurrence, recursive partitioning analyses classification, Karnofsky performance score, histology, and margin to the planning target volume. Only the last four showed significant association in the multivariate analyses. Conclusion. stereotactic radiosurgery is a safe and may be an effective treatment option for selected patients diagnosed with recurrent high-grade glioma. The identified prognostic factors could help individualise the treatment.
PB Hindawi Publishing Corporation
YR 2014
FD 2014-05-07
LK http://hdl.handle.net/10668/1852
UL http://hdl.handle.net/10668/1852
LA en
NO Martínez-Carrillo M, Tovar-Martín I, Zurita-Herrera M, Moral-Ávila R Del, Guerrero-Tejada R, Saura-Rojas E, et al. Salvage radiosurgery for selected patients with recurrent malignant gliomas. Biomed Res Int; 2014:657953
NO Journal Article;
DS RISalud
RD Mar 4, 2025