RT Journal Article
T1 Environmental Enrichment Rescues Endocannabinoid-Dependent Synaptic Plasticity Lost in Young Adult Male Mice after Ethanol Exposure during Adolescence.
A1 Rico-Barrio, Irantzu
A1 Peñasco, Sara
A1 Lekunberri, Leire
A1 Serrano, Maitane
A1 Egaña-Huguet, Jon
A1 Mimenza, Amaia
A1 Soria-Gomez, Edgar
A1 Ramos, Almudena
A1 Buceta, Ianire
A1 Gerrikagoitia, Inmaculada
A1 Mendizabal-Zubiaga, Juan
A1 Elezgarai, Izaskun
A1 Puente, Nagore
A1 Grandes, Pedro
K1 Drug addiction
K1 Endocannabinoid system
K1 Enrichment therapy
K1 Memory
K1 Synaptic plasticity
AB Binge drinking (BD) is a serious health concern in adolescents as high ethanol (EtOH) consumption can have cognitive sequelae later in life. Remarkably, an enriched environment (EE) in adulthood significantly recovers memory in mice after adolescent BD, and the endocannabinoid, 2-arachydonoyl-glycerol (2-AG), rescues synaptic plasticity and memory impaired in adult rodents upon adolescent EtOH intake. However, the mechanisms by which EE improves memory are unknown. We investigated this in adolescent male C57BL/6J mice exposed to a drinking in the dark (DID) procedure four days per week for a duration of 4 weeks. After DID, the mice were nurtured under an EE for 2 weeks and were subjected to the Barnes Maze Test performed the last 5 days of withdrawal. The EE rescued memory and restored the EtOH-disrupted endocannabinoid (eCB)-dependent excitatory long-term depression at the dentate medial perforant path synapses (MPP-LTD). This recovery was dependent on both the cannabinoid CB1 receptor and group I metabotropic glutamate receptors (mGluRs) and required 2-AG. Also, the EE had a positive effect on mice exposed to water through the transient receptor potential vanilloid 1 (TRPV1) and anandamide (AEA)-dependent MPP long-term potentiation (MPP-LTP). Taken together, EE positively impacts different forms of excitatory synaptic plasticity in water- and EtOH-exposed brains.
PB MDPI
SN 2227-9059
YR 2021
FD 2021-07-16
LK http://hdl.handle.net/10668/18305
UL http://hdl.handle.net/10668/18305
LA en
NO Rico-Barrio I, Peñasco S, Lekunberri L, Serrano M, Egaña-Huguet J, Mimenza A, et al. Environmental Enrichment Rescues Endocannabinoid-Dependent Synaptic Plasticity Lost in Young Adult Male Mice after Ethanol Exposure during Adolescence. Biomedicines. 2021 Jul 16;9(7):825
DS RISalud
RD Apr 19, 2025