RT Journal Article
T1 Pre-hospital antibiotic treatment and mortality caused by invasive meningococcal disease, adjusting for indication bias.
A1 Perea-Milla, Emilio
A1 Olalla, Julián
A1 Sánchez-Cantalejo, Emilio
A1 Martos, Francisco
A1 Matute-Cruz, Petra
A1 Carmona-López, Guadalupe
A1 Fornieles, Yolanda
A1 Cayuela, Aurelio
A1 García-Alegría, Javier
A1 Jiménez-Puente, Alberto
A1 Benitez-Parejo, Nicolás
A1 Rebollo, Natividad
A1 Rivas-Ruiz, Francisco
A1 Ruiz-Canela, MaPaz
A1 García-Martín, Francisco
A1 Sanchez-Perez, Maria-Jose
A1 Aguayo, Eduardo
A1 Daponte, Antonio
A1 Marquez, Soledad
A1 Nieto, Ma Teresa
A1 Romero-González, Julio
A1 Díaz-Cabrera, Rocío
A1 Lara, Antonio
K1 Administración Oral
K1 Antibacterianos
K1 Oportunidad Relativa
K1 Infecciones Meningocócicas
K1 Intervalos de Confianza
K1 Modelos Logísticos
K1 Estudios Retrospectivos
K1 Neisseria meningitidis
AB Background: Mortality from invasive meningococcal disease (IMD) has remained stable over the last thirty years and it is unclear whether pre-hospital antibiotherapy actually produces a decrease in this mortality. Our aim was to examine whether pre-hospital oral antibiotherapy reducesmortality from IMD, adjusting for indication bias.Methods: A retrospective analysis was made of clinical reports of all patients (n = 848) diagnosed with IMD from 1995 to 2000 in Andalusia and the Canary Islands, Spain, and of the relationship between the use of pre-hospital oral antibiotherapy and mortality. Indication bias was controlled for by the propensity score technique, and a multivariate analysis was performed to determine the probability of each patient receiving antibiotics, according to the symptoms identified before admission. Data on in-hospital death, use of antibiotics and demographic variables were collected.A logistic regression analysis was then carried out, using death as the dependent variable, and prehospital antibiotic use, age, time from onset of symptoms to parenteral antibiotics and thepropensity score as independent variables.Results: Data were recorded on 848 patients, 49 (5.72%) of whom died. Of the total number of patients, 226 had received oral antibiotics before admission, mainly betalactams during the previous 48 hours. After adjusting the association between the use of antibiotics and death for age, timebetween onset of symptoms and in-hospital antibiotic treatment, pre-hospital oral antibiotherapy remained a significant protective factor (Odds Ratio for death 0.37, 95% confidence interval 0.15–0.93).Conclusion: Pre-hospital oral antibiotherapy appears to reduce IMD mortality.
PB BioMed Central Ltd
YR 2009
FD 2009-04-03
LK http://hdl.handle.net/10668/717
UL http://hdl.handle.net/10668/717
LA en
NO Perea-Milla E, Olalla J, Sánchez-Cantalejo E, Martos F, Matute-Cruz P, Carmona-López G, et al. Pre-hospital antibiotic treatment and mortality caused by invasive meningococcal disease, adjusting for indication bias. BMC Public Health; 9:95
DS RISalud
RD Apr 20, 2025