RT Journal Article
T1 Hormonal Dependence and Cancer in Systemic Lupus Erythematosus.
A1 Cobo-Ibañez, Tatiana
A1 Urruticoechea-Arana, Ana
A1 Rua-Figueroa, Iñigo
A1 Martin-Martinez, Maria A
A1 Ovalles-Bonilla, Juan Gabriel
A1 Galindo, Maria
A1 Calvo-Alen, Jaime
A1 Olive, Alejandro
A1 Fernandez-Nebro, Antonio
A1 Menor-Almagro, Raul
A1 Tomero, Eva
A1 Horcada, Loreto
A1 Uriarte-Itzazelaia, Esther
A1 Martinez-Taboada, Victor M
A1 Andreu, Jose Luis
A1 Boteanu, Alina
A1 Narvaez, Javier
A1 Bohorquez, Cristina
A1 Montilla, Carlos
A1 Santos, Gregorio
A1 Hernandez-Cruz, Blanca
A1 Vela, Paloma
A1 Salgado, Eva
A1 Freire, Mercedes
A1 Hernandez-Beriain, Jose Angel
A1 Diez-Alvarez, Elvira
A1 Exposito, Lorena
A1 Fernandez-Berrizbeitia, Olaia
A1 Velloso-Feijoo, Maria Luisa
A1 Ibañez-Barcelo, Monica
A1 Lozano-Rivas, Nuria
A1 Bonilla, Gema
A1 Moreno, Mireia
A1 Raya, Enrique
A1 Quevedo-Vila, Victor Eliseo
A1 Vazquez-Rodriguez, Tomas Ramon
A1 Ibañez-Ruan, Jesus
A1 Muñoz-Fernandez, Santiago
A1 Sanchez-Alonso, Fernando
A1 Pego-Reigosa, Jose Maria
K1 Área de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de Cádiz
K1 Área de Gestión Sanitaria Sur de Sevilla
K1 Neoplasms
K1 Lupus Erythematosus, Systemic
K1 Rheumatology
K1 Hormones
AB To estimate the incidence and analyze any cancer-associated factors in patients with systemic lupus erythematosus (SLE), differentiating between hormone-sensitive (HS) and non-HS cancers. This was a retrospective multicenter study of a patient cohort from the Systemic Lupus Erythematosus Registry of the Spanish Society of Rheumatology. Included were the first cancer post-SLE diagnosis, clinical and sociodemographic information, cumulative damage, severity, comorbidities, treatments, and refractoriness. Cancers were classified as HS (prostate, breast, endometrium, and ovarian) and non-HS (the remainder). The standardized incidence ratio (SIR) was calculated and logistic regression models were built. A total of 3,539 patients (90.4% women) were included, 154 of whom had cancer (91% female), and 44 had HS cancer (100% female). The cancer SIR was 1.37 (95% confidence interval [95% CI] 1.15-1.59), with higher values in women age  Cancer incidence in patients with SLE was higher than in the Spanish population, particularly among young women. This increase might be due to non-HS cancers, which would be associated with SLE involving greater cumulative damage where more ACE inhibitors are prescribed.
PB Wiley
YR 2020
FD 2020-01-29
LK http://hdl.handle.net/10668/14514
UL http://hdl.handle.net/10668/14514
LA en
NO Cobo-Ibáñez T, Urruticoechea-Arana A, Rúa-Figueroa I, Martín-Martínez MA, Ovalles-Bonilla JG, Galindo M, et al. Hormonal Dependence and Cancer in Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). 2020 Feb;72(2):216-224
NO This work was supported by the Fondo de Investigación en Salud grant PI11/02857 (ISCIII, Fondo Europeo de Desarrollo Regional). Dr. Pego-Reigosa's work was supported by grant 316265 (BIOCAPS) from the European Union 7th Framework Program (FP7/REGPOT-2012-2013.1)
DS RISalud
RD Apr 10, 2025