%0 Journal Article
%A Cobo-Ibañez, Tatiana
%A Urruticoechea-Arana, Ana
%A Rua-Figueroa, Iñigo
%A Martin-Martinez, Maria A
%A Ovalles-Bonilla, Juan Gabriel
%A Galindo, Maria
%A Calvo-Alen, Jaime
%A Olive, Alejandro
%A Fernandez-Nebro, Antonio
%A Menor-Almagro, Raul
%A Tomero, Eva
%A Horcada, Loreto
%A Uriarte-Itzazelaia, Esther
%A Martinez-Taboada, Victor M
%A Andreu, Jose Luis
%A Boteanu, Alina
%A Narvaez, Javier
%A Bohorquez, Cristina
%A Montilla, Carlos
%A Santos, Gregorio
%A Hernandez-Cruz, Blanca
%A Vela, Paloma
%A Salgado, Eva
%A Freire, Mercedes
%A Hernandez-Beriain, Jose Angel
%A Diez-Alvarez, Elvira
%A Exposito, Lorena
%A Fernandez-Berrizbeitia, Olaia
%A Velloso-Feijoo, Maria Luisa
%A Ibañez-Barcelo, Monica
%A Lozano-Rivas, Nuria
%A Bonilla, Gema
%A Moreno, Mireia
%A Raya, Enrique
%A Quevedo-Vila, Victor Eliseo
%A Vazquez-Rodriguez, Tomas Ramon
%A Ibañez-Ruan, Jesus
%A Muñoz-Fernandez, Santiago
%A Sanchez-Alonso, Fernando
%A Pego-Reigosa, Jose Maria
%T Hormonal Dependence and Cancer in Systemic Lupus Erythematosus.
%D 2020
%U http://hdl.handle.net/10668/14514
%X To estimate the incidence and analyze any cancer-associated factors in patients with systemic lupus erythematosus (SLE), differentiating between hormone-sensitive (HS) and non-HS cancers. This was a retrospective multicenter study of a patient cohort from the Systemic Lupus Erythematosus Registry of the Spanish Society of Rheumatology. Included were the first cancer post-SLE diagnosis, clinical and sociodemographic information, cumulative damage, severity, comorbidities, treatments, and refractoriness. Cancers were classified as HS (prostate, breast, endometrium, and ovarian) and non-HS (the remainder). The standardized incidence ratio (SIR) was calculated and logistic regression models were built. A total of 3,539 patients (90.4% women) were included, 154 of whom had cancer (91% female), and 44 had HS cancer (100% female). The cancer SIR was 1.37 (95% confidence interval [95% CI] 1.15-1.59), with higher values in women age  Cancer incidence in patients with SLE was higher than in the Spanish population, particularly among young women. This increase might be due to non-HS cancers, which would be associated with SLE involving greater cumulative damage where more ACE inhibitors are prescribed.
%K Área de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de Cádiz
%K Área de Gestión Sanitaria Sur de Sevilla
%K Neoplasms
%K Lupus Erythematosus, Systemic
%K Rheumatology
%K Hormones
%~