RT Journal Article
T1 Association of plasma biomarkers of fruit and vegetable intake with incident type 2 diabetes: EPIC-InterAct case-cohort study in eight European countries.
A1 Zheng, Ju-Sheng
A1 Sharp, Stephen J
A1 Imamura, Fumiaki
A1 Chowdhury, Rajiv
A1 Gundersen, Thomas E
A1 Steur, Marinka
A1 Sluijs, Ivonne
A1 van der Schouw, Yvonne T
A1 Agudo, Antonio
A1 Aune, Dagfinn
A1 Barricarte, Aurelio
A1 Boeing, Heiner
A1 Chirlaque, María-Dolores
A1 Dorronsoro, Miren
A1 Freisling, Heinz
A1 El-Fatouhi, Douae
A1 Franks, Paul W
A1 Fagherazzi, Guy
A1 Grioni, Sara
A1 Gunter, Marc J
A1 Kyrø, Cecilie
A1 Katzke, Verena
A1 Kühn, Tilman
A1 Khaw, Kay-Tee
A1 Laouali, Nasser
A1 Masala, Giovanna
A1 Nilsson, Peter M
A1 Overvad, Kim
A1 Panico, Salvatore
A1 Papier, Keren
A1 Quirós, J Ramón
A1 Rolandsson, Olov
A1 Redondo-Sánchez, Daniel
A1 Ricceri, Fulvio
A1 Schulze, Matthias B
A1 Spijkerman, Annemieke M W
A1 Tjønneland, Anne
A1 Tong, Tammy Y N
A1 Tumino, Rosario
A1 Weiderpass, Elisabete
A1 Danesh, John
A1 Butterworth, Adam S
A1 Riboli, Elio
A1 Forouhi, Nita G
A1 Wareham, Nicholas J
AB To investigate the association of plasma vitamin C and carotenoids, as indicators of fruit and vegetable intake, with the risk of type 2 diabetes. Prospective case-cohort study. Populations from eight European countries. 9754 participants with incident type 2 diabetes, and a subcohort of 13 662 individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort of 340 234 participants: EPIC-InterAct case-cohort study. Incident type 2 diabetes. In a multivariable adjusted model, higher plasma vitamin C was associated with a lower risk of developing type 2 diabetes (hazard ratio per standard deviation 0.82, 95% confidence interval 0.76 to 0.89). A similar inverse association was shown for total carotenoids (hazard ratio per standard deviation 0.75, 0.68 to 0.82). A composite biomarker score (split into five equal groups), comprising vitamin C and individual carotenoids, was inversely associated with type 2 diabetes with hazard ratios 0.77, 0.66, 0.59, and 0.50 for groups 2-5 compared with group 1 (the lowest group). Self-reported median fruit and vegetable intake was 274 g/day, 396 g/day, and 508 g/day for participants in categories defined by groups 1, 3, and 5 of the composite biomarker score, respectively. One standard deviation difference in the composite biomarker score, equivalent to a 66 (95% confidence interval 61 to 71) g/day difference in total fruit and vegetable intake, was associated with a hazard ratio of 0.75 (0.67 to 0.83). This would be equivalent to an absolute risk reduction of 0.95 per 1000 person years of follow up if achieved across an entire population with the characteristics of the eight European countries included in this analysis. These findings indicate an inverse association between plasma vitamin C, carotenoids, and their composite biomarker score, and incident type 2 diabetes in different European countries. These biomarkers are objective indicators of fruit and vegetable consumption, and suggest that diets rich in even modestly higher fruit and vegetable consumption could help to prevent development of type 2 diabetes.
YR 2020
FD 2020-07-08
LK http://hdl.handle.net/10668/15902
UL http://hdl.handle.net/10668/15902
LA en
DS RISalud
RD Apr 8, 2025