RT Journal Article
T1 Autophagy in Hematological Malignancies.
A1 Garcia Ruiz, Olga
A1 Sanchez-Maldonado, Jose Manuel
A1 Lopez-Nevot, Miguel Angel
A1 Garcia, Paloma
A1 Macauda, Angelica
A1 Hernandez-Mohedo, Francisca
A1 Gonzalez-Sierra, Pedro Antonio
A1 Martinez-Bueno, Manuel
A1 Perez, Eva
A1 Reyes-Zurita, Fernando Jesus
A1 Campa, Daniele
A1 Canzian, Federico
A1 Jurado, Manuel
A1 Rodriguez-Sevilla, Juan Jose
A1 Sainz, Juan
K1 autophagy
K1 autophagy-related variants
K1 clinical outcomes
K1 disease progression
K1 hematological malignancies
K1 hematopoiesis
K1 patient survival
K1 therapeutic target
AB Autophagy is a highly conserved metabolic pathway via which unwanted intracellular materials, such as unfolded proteins or damaged organelles, are digested. It is activated in response to conditions of oxidative stress or starvation, and is essential for the maintenance of cellular homeostasis and other vital functions, such as differentiation, cell death, and the cell cycle. Therefore, autophagy plays an important role in the initiation and progression of tumors, including hematological malignancies, where damaged autophagy during hematopoiesis can cause malignant transformation and increase cell proliferation. Over the last decade, the importance of autophagy in response to standard pharmacological treatment of hematological tumors has been observed, revealing completely opposite roles depending on the tumor type and stage. Thus, autophagy can promote tumor survival by attenuating the cellular damage caused by drugs and/or stabilizing oncogenic proteins, but can also have an antitumoral effect due to autophagic cell death. Therefore, autophagy-based strategies must depend on the context to create specific and safe combination therapies that could contribute to improved clinical outcomes. In this review, we describe the process of autophagy and its role on hematopoiesis, and we highlight recent research investigating its role as a potential therapeutic target in hematological malignancies. The findings suggest that genetic variants within autophagy-related genes modulate the risk of developing hemopathies, as well as patient survival.
PB MDPI AG
SN 2072-6694
YR 2022
FD 2022-10-13
LK http://hdl.handle.net/10668/20922
UL http://hdl.handle.net/10668/20922
LA en
NO García Ruiz O, Sánchez-Maldonado JM, López-Nevot MÁ, García P, Macauda A, Hernández-Mohedo F, et al . Autophagy in Hematological Malignancies. Cancers (Basel). 2022 Oct 17;14(20):5072.
DS RISalud
RD Apr 11, 2025