RT Journal Article
T1 External validation of a prognostic model based on total tumor load of sentinel lymph node for early breast cancer patients.
A1 Piñero-Madrona, Antonio
A1 Ripoll-Orts, Francisco
A1 Sánchez-Méndez, José Ignacio
A1 Chaves-Benito, Asunción
A1 Gómez-de la Bárcena, Maximiliano Rodrigo
A1 Calatrava-Fons, Ana
A1 Menjón-Beltrán, Salomón
A1 Peg-Cámara, Vicente
K1 Breast cancer
K1 Model validation
K1 Prognosis
K1 Sentinel lymph node
K1 Total tumor load
AB A prognostic model based on the results of molecular analysis of sentinel lymph nodes (SLN) is needed to replace the information that staging the entire axilla provided. The aim of the study is to conduct an external validation of a previously developed model for the prediction of 5-year DFS in a group of breast cancer patients that had undergone SLN biopsy assessed by the One Step Nucleic Acid Amplification (OSNA) method. We collected retrospective data of 889 patients with breast cancer, who had not received systemic treatment before surgery, and who underwent SLN biopsy and evaluation of all SLN by OSNA. The discrimination ability of the model was assessed by the area under the ROC curve (AUC ROC), and its calibration by comparing 5-years DFS Kaplan-Meier estimates in quartile groups of model predicted probabilities (MPP). The AUC ROC ranged from 0.78 (at 2 years) to 0.73 (at 5 years) in the training set, and from 0.78 to 0.71, respectively, in the validation set. The MPP allowed to distinguish four groups of patients with heterogeneous DFS (log-rank test p  The model for the prediction of 5-year DFS was successfully validated using the most stringent form of validation, in centers different from those involved in the development of the model. The external validation of the model confirms its utility for the prediction of 5-year DFS and the usefulness of the TTL value as a prognostic variable.
YR 2020
FD 2020-04-06
LK http://hdl.handle.net/10668/15332
UL http://hdl.handle.net/10668/15332
LA en
DS RISalud
RD Apr 5, 2025