RT Journal Article
T1 Long-Chain Polyunsaturated Fatty Acids, Homocysteine at Birth and Fatty Acid Desaturase Gene Cluster Polymorphisms are Associated with Children's Processing Speed up to Age 9 Years.
A1 Campoy, Cristina
A1 Azaryah, Hatim
A1 Torres-Espinola, Francisco J
A1 Martínez-Zaldivar, Cristina
A1 Garcia-Santos, Jose Antonio
A1 Demmelmair, Hans
A1 Haile, Gudrun
A1 Györei, Eszter
A1 Ramirez-Tortosa, Maria Del Carmen
A1 Reischl, Eva
A1 Rzehak, Peter
A1 Molloy, Anne M
A1 Decsi, Tamas
A1 Luna, Juan de Dios
A1 Koletzko, Berthold
A1 Perez-Garcia, Miguel
K1 FADS gene
K1 children
K1 folate
K1 long-chain polyunsaturated fatty acids
K1 neurodevelopment
K1 prenatal supplementation
K1 processing speed
AB Both pre- and early postnatal supplementation with docosahexaenoic acid (DHA), arachidonic acid (AA) and folate have been related to neural development, but their long-term effects on later neural function remain unclear. We evaluated the long-term effects of maternal prenatal supplementation with fish-oil (FO), 5-methyltetrahydrofolate (5-MTHF), placebo or FO + 5-MTHF, as well as the role of fatty acid desaturase (FADS) gene cluster polymorphisms, on their offspring's processing speed at later school age. This study was conducted in NUHEAL children at 7.5 (n = 143) and 9 years of age (n = 127). Processing speed tasks were assessed using Symbol Digit Modalities Test (SDMT), Children Color Trails Test (CCTT) and Stroop Color and Word Test (SCWT). Long-chain polyunsaturated fatty acids, folate and total homocysteine (tHcy) levels were determined at delivery from maternal and cord blood samples. FADS and methylenetetrahydrofolate reductase (MTHFR) 677 C > T genetic polymorphisms were analyzed. Mixed models (linear and logistic) were performed. There were significant differences in processing speed performance among children at different ages (p  T genetic polymorphisms were analyzed. Mixed models (linear and logistic) were performed. There were significant differences in processing speed performance among children at different ages (p
PB MDPI AG
YR 2020
FD 2020-12-31
LK http://hdl.handle.net/10668/16913
UL http://hdl.handle.net/10668/16913
LA en
NO Campoy C, Azaryah H, Torres-Espínola FJ, Martínez-Zaldívar C, García-Santos JA, Demmelmair H, et al. Long-Chain Polyunsaturated Fatty Acids, Homocysteine at Birth and Fatty Acid Desaturase Gene Cluster Polymorphisms are Associated with Children's Processing Speed up to Age 9 Years. Nutrients. 2020 Dec 31;13(1):131.
NO This work was supported by the Commission of the European Community’s 7th Framework Program (FP7/2008-2013), Grant agreement no. 212652 (NUTRIMENTHE Project); within the 6th Framework Program, Contract no. 007036 (EARNEST Project); and supported in part by the Commission of the European Community within the 5th Framework Program, Contract no. QLK1-CT-1999-00888 (NUHEAL EU Project). This publication is the work of the authors and does not necessarily reflect the views of the Commission of the European Community. The work of B.K. is supported by the European Commission, H2020 Programmes DYNAHEALTH-633595 und Lifecycle-733206, the European Research Council Advanced Grant META-GROWTH ERC-2012-AdG–no.322605, the Erasmus Plus Programmes Early Nutrition eAcademy Southeast Asia-573651-EPP-1-2016-1-DE-EPPKA2-CBHE-JP and Capacity Building to Improve Early Nutrition and Health in South Africa-598488-EPP-1-2018-1-DE-EPPKA2-CBHE-JP, the EU Interreg Programme Focus in CD-CE111 and the European Joint Programming Initiative Project NutriPROGRAM and EndObesity, the German Ministry of Education and Research, Berlin (Grant Nr. 01 GI 0825), and the German Research Council (Ko912/12-1 and INST 409/224-1 FUGG). BK is the Else Kröner-Senior professor of Paediatrics at LMU financially supported by the Else Kröner-Fresenius-Foundation and LMU University Hospitals. Funders had no role in the design, analysis or writing of this article.
DS RISalud
RD Apr 5, 2025