RT Journal Article
T1 Organic/inorganic hydrogels by simultaneous self-assembly and mineralization of aromatic short-peptides
A1 Manas-Torres, Mari C.
A1 Ramirez-Rodriguez, Gloria B.
A1 Garcia-Peiro, Jose, I
A1 Parra-Torrejon, Belen
A1 Cuerva, Juan M.
A1 Lopez-Lopez, Modesto T.
A1 Alvarez de Cienfuegos, Luis
A1 Delgado-Lopez, Jose M.
K1 Supramolecular hydrogels
K1 Biomimetic scaffolds
K1 Composite scaffolds
K1 Hybrid hydrogels
K1 Building-blocks
K1 Gel phase
K1 Dipeptide
K1 Protein
K1 Growth
K1 Biomineralization
AB Self-assembled peptides and proteins have turned out to be excellent templates for the growth of inorganic minerals and can be used to emulate natural biomineralization processes. Doing this, researchers have developed complex sophisticated materials with properties, in some cases, similar to those found in nature. Of special interest is the development of scaffolds able to guide bone regeneration. The bone tissue comprises an organic matrix composed of aligned collagen fibers containing nanoapatite crystals oriented along the fiber direction. During bone mineralization, both processes, the self-assembly of collagen fibrils and mineralization occur simultaneously. Collagen fibers are able to control calcium phosphate nucleation and subsequent apatite crystal growth at a very limited range of collagen density and ionic concentration. In this study, we reproduced the simultaneity of both processes using an artificial peptide fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) that has the ability to self-assemble in water after the addition of Ca2+ ions. Therefore, the peptide self-assembly process and the mineralization of apatite are Ca-demanding processes and occur simultaneously. The role of peptide and ionic concentrations has been investigated affording organic/inorganic hybrid hydrogels with different degrees of homogeneity and mineralization. Interestingly, at very low Ca2+ concentrations, we found that apatite nanocrystals are integrated into Fmoc-FF fibrils and oriented as in biologically mineralized collagen fibrils, the basic building blocks of bone.
PB Royal soc chemistry
PB Royal Society of Chemistry
SN 2052-1553
YR 2021
FD 2021-12-17
LK http://hdl.handle.net/10668/19641
UL http://hdl.handle.net/10668/19641
LA en
NO Manas-Torres, Mari C.Ramirez-Rodriguez, Gloria B.Garcia-Peiro, Jose, IParra-Torrejon, BelenCuerva, Juan M.Lopez-Lopez, Modesto T., et al.  Organic/inorganic hydrogels by simultaneous self-assembly and mineralization of aromatic short-peptides. Inorg. chem. front. ValorLangEditar2021-12-17. 9. 743-752.
NO This study was supported by projects RTI-2018-095794-A-C22,RYC-2016-21042 and project PID2020-118498GB-I00 funded byMCIN/AEI/10.13039/501100011033 and projects P18-FR-3533and P18-TP-0969 by FEDER/Junta de Andalucía-Consejería deTransformación Económica, Industria, Conocimiento yUniversidades (Spain). Thanks go to the CIC personnel of theUniversity of Granada for technical assistance. MCMT acknowledges grant PRE2018-083773 funded by MCIN/AEI/10.13039/501100011033 and FSE “El FSE invierte en tu futuro”, Spain.GBRR also acknowledges Junta de Andalucia for her postdoctoral contract within the PAIDI 2020 program (DOC_01383).
DS RISalud
RD Apr 10, 2025