RT Journal Article
T1 Changes in SCD gene DNA methylation after bariatric surgery in morbidly obese patients are associated with free fatty acids.
A1 Morcillo, Sonsoles
A1 Martin-Nuñez, Gracia Mª
A1 Garcia-Serrano, Sara
A1 Gutierrez-Repiso, Carolina
A1 Rodriguez-Pacheco, Francisca
A1 Valdes, Sergio
A1 Gonzalo, Montserrat
A1 Rojo-Martinez, Gemma
A1 Moreno-Ruiz, Francisco J
A1 Rodriguez-Cañete, Alberto
A1 Tinahones, Francisco
A1 Garcia-Fuentes, Eduardo
K1 Bariatric Surgery
K1 DNA Methylation
K1 Epigenesis, Genetic
K1 Fatty Acids, Nonesterified
AB Stearoyl CoA Desaturase-1 (SCD) is considered as playing an important role in the explanation of obesity. The aim of this study was to evaluate whether the DNA methylation SCD gene promoter is associated with the metabolic improvement in morbidly obese patients after bariatric surgery. The study included 120 subjects with morbid obesity who underwent a laparoscopic Roux-en Y gastric by-pass (RYGB) and a control group of 30 obese subjects with a similar body mass index (BMI) to that found in morbidly obese subjects six months after RYGB. Fasting blood samples were obtained before and at six months after RYGB. DNA methylation was measured by pyrosequencing technology. DNA methylation levels of the SCD gene promoter were lower in morbidly obese subjects before bariatric surgery but increased after RYGB to levels similar to those found in the control group. Changes of DNA methylation SCD gene were associated with the changes of free fatty acids levels (r = -0.442, p = 0.006) and HOMA-IR (r = -0.249, p = 0.035) after surgery. RYGB produces an increase in the low SCD methylation promoter levels found in morbidly obese subjects. This change of SCD methylation levels is associated with changes in FFA and HOMA-IR.
PB  Springer Nature
YR 2017
FD 2017-04-10
LK http://hdl.handle.net/10668/11075
UL http://hdl.handle.net/10668/11075
LA en
NO Morcillo S, Martín-Núñez GM, García-Serrano S, Gutierrez-Repiso C, Rodriguez-Pacheco F, Valdes S, et al. Gonzalo M, Rojo-Martinez G, Moreno-Ruiz FJ, Rodriguez-Cañete A, Tinahones F, García-Fuentes E. Changes in SCD gene DNA methylation after bariatric surgery in morbidly obese patients are associated with free fatty acids. Sci Rep. 2017 Apr 10;7:46292
NO This study has been supported by “Centros de Investigación En Red” (CIBEROBN, CB06/03/0018) of the “Instituto de Salud Carlos III” (ISCIII); PI15/01350 from the ISCIII, and from the Consejería de Economía, Innovación, Ciencia y Empresa de la Junta de Andalucía, Spain (CTS-8081), and cofinanced by the European Regional Development Fund (FEDER, “Una manera de hacer Europa”).
DS RISalud
RD Apr 6, 2025