RT Journal Article
T1 Pediatric parapneumonic empyema, Spain
A1 Obando, Ignacio
A1 Muñoz-Almagro, Carmen
A1 Arroyo, Luis A
A1 Tarrago, David
A1 Sanchez-Tatay, David
A1 Moreno-Perez, David
A1 Dhillon, Sahar S
A1 Esteva, Cristina
A1 Hernandez-Bou, Susanna
A1 Garcia-Garcia, Juan J
A1 Hausdorff, William P
A1 Brueggemann, Angela B
K1 Preescolar
K1 Empiema Pleural
K1 Genotipo
K1 Humanos
K1 Lactante
K1 Epidemiología Molecular
K1 Neumonía Neumocócica
K1 Estudios Prospectivos
K1 Estudios Retrospectivos
K1 España
K1 Streptococcus pneumoniae
K1 Niño
AB Pediatric parapneumonic empyema (PPE) has been increasing in several countries including Spain. Streptococcus pneumoniae is a major PPE pathogen; however, antimicrobial pretreatment before pleural fluid (PF) sampling frequently results in negative diagnostic cultures, thus greatly underestimating the contribution of pneumococci, especially pneumococci susceptible to antimicrobial agents, to PPE. The study aim was to identify the serotypes and genotypes that cause PPE by using molecular diagnostics and relate these data to disease incidence and severity. A total of 208 children with PPE were prospectively enrolled; blood and PF samples were collected. Pneumococci were detected in 79% of culture-positive and 84% of culture-negative samples. All pneumococci were genotyped by multilocus sequence typing. Serotypes were determined for 111 PPE cases; 48% were serotype 1, of 3 major genotypes previously circulating in Spain. Variance in patient complication rates was statistically significant by serotype. The recent PPE increase is principally due to nonvaccine serotypes, especially the highly invasive serotype 1.
PB Centers for Disease Control and Prevention
SN 1080-6040
YR 2008
FD 2008-09-09
LK http://hdl.handle.net/10668/1795
UL http://hdl.handle.net/10668/1795
LA en
NO Obando I, Muñoz-Almagro C, Arroyo LA, Tarrago D, Sanchez-Tatay D, Moreno-Perez D, et al. Pediatric parapneumonic empyema, Spain. Emerging Infect. Dis. 2008; 14(9):1390-7
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 8, 2025