RT Journal Article
T1 Validity and reliability of the Spanish version of the DN4 (Douleur Neuropathique 4 questions) questionnaire for differential diagnosis of pain syndromes  associated to a neuropathic or somatic component
A1 Perez, Concepcion
A1 Galvez, Rafael
A1 Huelbes, Silvia
A1 Insausti, Joaquin
A1 Bouhassira, Didier
A1 Diaz, Silvia
A1 Rejas, Javier
K1 Diagnóstico Diferencial
K1 Femenino
K1 Humanos
K1 Masculino
K1 Mediana Edad
K1 Dolor
K1 Enfermedades del Sistema Nervioso Periférico
K1 Psicometría
K1 Cuestionarios
K1 Trastornos Somatosensoriales
K1 España
K1 Síndrome
K1 Traducciones
K1 Anciano
AB BACKGROUNDThis study assesses the validity and reliability of the Spanish version of DN4 questionnaire as a tool for differential diagnosis of pain syndromes associated to a neuropathic (NP) or somatic component (non-neuropathic pain, NNP).METHODSA study was conducted consisting of two phases: cultural adaptation into the Spanish language by means of conceptual equivalence, including forward and backward translations in duplicate and cognitive debriefing, and testing of psychometric properties in patients with NP (peripheral, central and mixed) and NNP. The analysis of psychometric properties included reliability (internal consistency, inter-rater agreement and test-retest reliability) and validity (ROC curve analysis, agreement with the reference diagnosis and determination of sensitivity, specificity, and positive and negative predictive values in different subsamples according to type of NP).RESULTSA sample of 164 subjects (99 women, 60.4%; age: 60.4 +/- 16.0 years), 94 (57.3%) with NP (36 with peripheral, 32 with central, and 26 with mixed pain) and 70 with NNP was enrolled. The questionnaire was reliable [Cronbach's alpha coefficient: 0.71, inter-rater agreement coefficient: 0.80 (0.71-0.89), and test-retest intra-class correlation coefficient: 0.95 (0.92-0.97)] and valid for a cut-off value > or = 4 points, which was the best value to discriminate between NP and NNP subjects.DISCUSSIONThis study, representing the first validation of the DN4 questionnaire into another language different than the original, not only supported its high discriminatory value for identification of neuropathic pain, but also provided supplemental psychometric validation (i.e. test-retest reliability, influence of educational level and pain intensity) and showed its validity in mixed pain syndromes.
PB BioMed Central
YR 2007
FD 2007-12-04
LK http://hdl.handle.net/10668/640
UL http://hdl.handle.net/10668/640
LA en
NO Perez C, Galvez R, Huelbes S, Insausti J, Bouhassira D,  Diaz S et al. Validity and reliability of the Spanish version of the DN4 (Douleur Neuropathique 4 questions) questionnaire for differential diagnosis of pain syndromes associated to a neuropathic or somatic components. Health Qual Life Outcomes. 2007 Dec 4;5:66.
NO Preliminary results have been presented as a poster at 5th Congress of theEuropean Federation of IASP Chapters (EFIC), Istanbul, 2006.  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies;
DS RISalud
RD Apr 19, 2025