RT Journal Article
T1 Different profiles of advanced heart failure among patients with and without diabetes mellitus. Findings from the EPICTER study.
A1 Lorido, José Carlos Arévalo
A1 Gómez, Juana Carretero
A1 Correa, Miriam Romero
A1 Iglesias, Jesus Recio
A1 Fernández, Teresa Choucino
A1 Camajuncosa, Rosa Jordana
A1 Izquierdo, Margarita Carrera
A1 Guardiola, Carlos Jiménez
A1 Pardo, Lucía Fuentes
A1 Ruiz, Esther Piniella
A1 Formiga, Francesc
A1 Bautista, Prado Salamanca
K1 Advanced heart failure
K1 Diabetes Mellitus
K1 Diabetes complications
K1 Palliative care
AB This work aims to compare the characteristics of advanced heart failure (HF) in patients with and without type 2 diabetes mellitus (DM) and to determine the relevance of variables used to define advanced HF. This cross-sectional, multicenter study included patients hospitalized for HF. They were classified into four groups according to presence/absence of advanced HF, determined based on general and cardiac criteria, and presence/absence of DM. To analyze the importance of variables, we grew a random forest algorithm (RF) based on mortality at six months. A total of 3153 patients were included. The prevalence of advanced HF among patients with DM was 24% compared to 23% among those without DM (p=0.53). Patients with advanced HF and DM had more comorbidity related to cardiovascular and renal diseases; their prognosis was the poorest (log-rank <0.0001) though the adjusted hazard ratio by group in the Cox regression analysis was not significant. The variables that were significantly related to mortality were the number of comorbidities (p=0.005) and systolic blood pressure (p=0.024). The RF showed that general criteria were more important for defining advanced HF than cardiac criteria. Patients with advanced HF and DM were characterized by DM in progression with macro and microvascular complications. The outcomes among advanced HF patients were poor; patients with advanced HF and DM had the poorest outcomes. General criteria were the most important to establish accurately a definition of advanced HF, being decisive the evidence of disease progression in patients with DM.
YR 2022
FD 2022-07-22
LK http://hdl.handle.net/10668/22183
UL http://hdl.handle.net/10668/22183
LA en
DS RISalud
RD Apr 10, 2025