RT Journal Article
T1 Plasma Levels of Mid-Regional Proadrenomedullin Accurately Identify H1N1pdm09 Influenza Virus Patients with Risk of Intensive Care Admission and Mortality in the Emergency Department.
A1 Valenzuela-Méndez, Blanca
A1 Valenzuela-Sánchez, Francisco
A1 Rodríguez-Gutiérrez, Juan Francisco
A1 Bohollo-de-Austria, Rafael
A1 Estella, Ángel
A1 Martínez-García, Pilar
A1 González-García, María Ángela
A1 Rello, Jordi
K1 CRP
K1 H1N1 influenza pneumonia
K1 ICU admission
K1 MR proadrenomedullin
K1 biomarkers
K1 ferritin
K1 procalcitonin
K1 sepsis
K1 virus
AB Early identification of severe viral pneumonia in influenza virus A (H1N1pdm09) patients is extremely important for prompt admission to the ICU. The objective is to evaluate the usefulness of MR-proadrenomedullin (MR-proADM) compared to C reactive protein (CRP), procalcitonin (PCT), and ferritin in the prognosis of influenza A pneumonia. This prospective, observational, multicenter study included one hundred thirteen patients with confirmed influenza virus A (H1N1pdm09) admitted to an Emergency Department and ICUs of six hospitals in Spain. Measurements and Main Results: one-hundred thirteen patients with confirmed influenza virus A (H1N1pdm09) were enrolled. Seventy-five subjects (mortality 29.3%) with severe pneumonia caused by influenza A H1N1pdm09 virus (H1N1vIPN) were compared with 38 controls (CG).The median MR-proADM levels at hospital admission were 1.2 nmol/L (IQR (0.8-2.6) vs. 0.5 nmol/L (IQR 0.2-0.9) in the CG (p = 0.01), and PCT levels were 0.43 μg/L (IQR 0.2-1.2) in the H1N1vIPN group and 0.1 μg/L (IQR 0.1-0.2) in the CG (p  1.2 nmol/L at hospital admission were significant predictive factors for ICU and 90-day mortality (HR: 1.3). Conclusions: the initial MR-proADM, ferritin, CRP, and PCT levels effectively determine adverse outcomes and risk of ICU admission and mortality in patients with influenza virus pneumonia. MR-proADM has the highest potency for survival prediction.
SN 2075-4426
YR 2022
FD 2022-01-10
LK http://hdl.handle.net/10668/21370
UL http://hdl.handle.net/10668/21370
LA en
DS RISalud
RD Apr 7, 2025