RT Journal Article
T1 Standardization and Chemical Characterization of Intravenous Therapy in Adult Patients: A Step Further in Medication Safety.
A1 Manrique-Rodriguez, Silvia
A1 Heras-Hidalgo, Irene
A1 Pernia-Lopez, M Sagrario
A1 Herranz-Alonso, Ana
A1 Del Rio Pisabarro, M Camino
A1 Suarez-Mier, M Belen
A1 Cubero-Perez, M Antonia
A1 Viera-Rodriguez, Veronica
A1 Cortes-Rey, Noemi
A1 Lafuente-Cabrero, Elizabeth
A1 Martinez-Ortega, M Carmen
A1 Bermejo-Lopez, Esther
A1 Diez-Saenz, Cristina
A1 Lopez-Sanchez, Piedad
A1 Gaspar-Carreño, M Luisa
A1 Achau-Muñoz, Ruben
A1 Marquez-Peiro, Juan F
A1 Valera-Rubio, Marta
A1 Domingo-Chiva, Esther
A1 Aquerreta-Gonzalez, Irene
A1 Ariño, Ignacio Pellin
A1 Martin-Delgado, M Cruz
A1 Herrera-Gutierrez, Manuel
A1 Gordo-Vidal, Federico
A1 Rascado-Sedes, Pedro
A1 Garcia-Prieto, Emilio
A1 Fernandez-Sanchez, Lucas J
A1 Fox-Carpentieri, Sara
A1 Lamela-Piteira, Carlos
A1 Guerra-Sanchez, Luis
A1 Jimenez-Aguado, Miguel
A1 Sanjurjo-Saez, Maria
K1 Osmolar Concentration
K1 Phlebitis
K1 Spain
K1 Vascular Access Devices
AB Intravenous drug administration is associated with potential complications, such as phlebitis. The physiochemical characteristics of the infusate play a very important role in some of these problems. The aim of this study was to standardize the dilutions of intravenous drugs most commonly used in hospitalized adult patients and to characterize their pH, osmolarity and cytotoxic nature to better guide the selection of the most appropriate vascular access. The project was conducted in three phases: (i) standardization of intravenous therapy, which was conducted using a modified double-round Delphi method; (ii) characterization of the dilutions agreed on in the previous phase by means of determining the osmolarity and pH of each of the agreed concentrations, and recording the vesicant nature based on the information in literature; and (iii) algorithm proposal for selecting the most appropriate vascular access, taking into account the information gathered in the previous phases. In total, 112 drugs were standardized and 307 different admixtures were assessed for pH, osmolarity and vesicant nature. Of these, 123 admixtures (40%), had osmolarity values >600 mOsm/L, pH 600 mOsm/L, pH  9, or were classified as vesicants. In these cases, selection of the most suitable route of infusion and vascular access device is crucial to minimize the risk of phlebitis-type complications. Increasing safety of intravenous therapy should be a priority in the healthcare settings. Knowing the characteristics of drugs to assess the risk involved in their administration related to their physicochemical nature may be useful to guide decision making regarding the most appropriate vascular access and devices.
PB Springer
YR 2020
FD 2020-12-21
LK http://hdl.handle.net/10668/16829
UL http://hdl.handle.net/10668/16829
LA en
NO Manrique-Rodríguez S, Heras-Hidalgo I, Pernia-López MS, Herranz-Alonso A, Del Río Pisabarro MC, Suárez-Mier MB, et al. Standardization and Chemical Characterization of Intravenous Therapy in Adult Patients: A Step Further in Medication Safety. Drugs R D. 2021 Mar;21(1):39-64. doi: 10.1007/s40268-020-00329-w. Epub 2020 Dec 21. Erratum in: Drugs R D. 2021 Jun;21(2):239-265
DS RISalud
RD Apr 8, 2025