%0 Journal Article
%A Vogt, Elinor Chelsom
%A Real, Francisco Gómez
%A Husebye, Eystein Sverre
%A Björnsdottir, Sigridur
%A Benediktsdottir, Bryndis
%A Bertelsen, Randi Jacobsen
%A Demoly, Pascal
%A Franklin, Karl Anders
%A de Aja Gallastegui, Leire Sainz
%A González, Francisco Javier Callejas
%A Heinrich, Joachim
%A Holm, Mathias
%A Jogi, Nils Oscar
%A Leynaert, Benedicte
%A Lindberg, Eva
%A Malinovschi, Andrei
%A Martínez-Moratalla, Jesús
%A Mayoral, Raúl Godoy
%A Oudin, Anna
%A Pereira-Vega, Antonio
%A Semjen, Chantal Raherison
%A Schlünssen, Vivi
%A Triebner, Kai
%A Øksnes, Marianne
%T Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts.
%D 2022
%@ 2049-3614
%U http://hdl.handle.net/10668/20440
%X To investigate markers of premature menopause ( Postmenopausal women were categorized according to age at menopause and self-reported reason for menopause in a cross-sectional analysis of 6870 women. Variables associated with the timing of menopause and hormone measurements of 17β-estradiol and follicle-stimulating hormone were explored using multivariable logistic regression analysis. Specific immunoprecipitating assays of steroidogenic autoantibodies against 21-hydroxylase (21-OH), side-chain cleavage enzyme (anti-SCC) and 17alpha-hydroxylase (17 OH), as well as NACHT leucine-rich-repeat protein 5 were used to identify women with likely autoimmune POI. Premature menopause was identified in 2.8% of women, and these women had higher frequencies of nulliparity (37.4% vs 19.7%), obesity (28.7% vs 21.4%), osteoporosis (17.1% vs 11.6%), hormone replacement therapy (59.1% vs 36.9%) and never smokers (60.1% vs 50.9%) (P  Idiopathic POI affects 1.1% of all women and almost half of the women with premature menopause. Autoimmunity explains 4.5% of these cases judged by positive steroidogenic autoantibodies.
%K autoimmune
%K premature menopause
%K premature ovarian failure
%K premature ovarian insufficiency
%K primary ovarian insufficiency
%~