%0 Journal Article
%A van Woudenbergh, Geertruida J.
%A Kuijsten, Anneleen
%A Drogan, Dagmar
%A Boeing, Heiner
%A Schulze, Matthias B.
%A van der A, Daphne L.
%A Bueno-de-Mesquita, H. Bas
%A Spijkerman, Annemieke M. W.
%A Romaguera, Dora
%A Riboli, Elio
%A Ardanaz, Eva
%A Barricarte, Aurelio
%A Amiano, Pilar
%A Beulens, Joline W. J.
%A Sluijs, Ivonne
%A Dahm, Christina C
%A Overvad, Kim
%A Chirlaque, M-Doleres
%A Clavel, Francoise
%A Fagher-azzi, Guy
%A Crowe, Francesca L.
%A Eomois, Piia-Piret
%A Teucher, Birgit
%A Franks, Paul W.
%A Halkjaer, Jytte
%A Tjonneland, Anne
%A Khaw, Kay T.
%A Masala, Giovanna
%A Mattiello, Amalia
%A Quiros, J. Ramon
%A Rolandsson, Olov
%A Romieu, Isabelle
%A Sacerdote, Carlotta
%A Sanchez-Perez, Maria-Jose
%A Tagliabue, Giovanna
%A Tumino, Rosario
%A Forouhi, Nita G.
%A Sharp, Stephen
%A Langenberg, Claudia
%A Wareham, Nicholas J.
%T Tea consumption and incidence of type 2 diabetes in Europe: the EPIC-InterAct case-cohort study.
%D 2012
%U http://hdl.handle.net/10668/769
%X BACKGROUNDIn previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incidence of type 2 diabetes in a European population.METHODOLOGY/PRINCIPAL FINDINGSThe EPIC-InterAct case-cohort study was conducted in 26 centers in 8 European countries and consists of a total of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,835 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Country-specific Hazard Ratios (HR) for incidence of type 2 diabetes were obtained after adjustment for lifestyle and dietary factors using a Cox regression adapted for a case-cohort design. Subsequently, country-specific HR were combined using a random effects meta-analysis. Tea consumption was studied as categorical variable (0, >0-<1, 1-<4, ≥ 4 cups/day). The dose-response of the association was further explored by restricted cubic spline regression. Country specific medians of tea consumption ranged from 0 cups/day in Spain to 4 cups/day in United Kingdom. Tea consumption was associated inversely with incidence of type 2 diabetes; the HR was 0.84 [95%CI 0.71, 1.00] when participants who drank ≥ 4 cups of tea per day were compared with non-drinkers (p(linear trend) = 0.04). Incidence of type 2 diabetes already tended to be lower with tea consumption of 1-<4 cups/day (HR = 0.93 [95%CI 0.81, 1.05]). Spline regression did not suggest a non-linear association (p(non-linearity) = 0.20).CONCLUSIONS/SIGNIFICANCEA linear inverse association was observed between tea consumption and incidence of type 2 diabetes. People who drink at least 4 cups of tea per day may have a 16% lower risk of developing type 2 diabetes than non-tea drinkers.
%K Té
%K Adulto
%K Anciano
%K Estudios de Cohortes
%K Diabetes Mellitus Tipo 2
%K Conducta de Ingestión de Líquido
%K Europa
%K Femenino
%K Humanos
%K Masculino
%K Mediana Edad
%K Dinámicas no Lineales
%K Cuestionarios
%K Riesgo
%K Adulto Joven
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