RT Journal Article
T1 Prenatal Ambient Air Pollution, Placental Mitochondrial DNA Content, and Birth Weight in the INMA (Spain) and ENVIRONAGE (Belgium) Birth Cohorts.
A1 Clemente, Diana B P
A1 Casas, Maribel
A1 Vilahur, Nadia
A1 Begiristain, Haizea
A1 Bustamante, Mariona
A1 Carsin, Anne-Elie
A1 Fernández, Mariana F
A1 Fierens, Frans
A1 Gyselaers, Wilfried
A1 Iñiguez, Carmen
A1 Janssen, Bram G
A1 Lefebvre, Wouter
A1 Llop, Sabrina
A1 Olea, Nicolás
A1 Pedersen, Marie
A1 Pieters, Nicky
A1 Santa Marina, Loreto
A1 Souto, Ana
A1 Tardón, Adonina
A1 Vanpoucke, Charlotte
A1 Vrijheid, Martine
A1 Sunyer, Jordi
A1 Nawrot, Tim S
K1 Contaminación del aire
K1 Bélgica
K1 Peso al nacer
K1 ADN mitocondrial
K1 Femenino
K1 Desarrollo fetal
K1 Retardo del crecimiento fetal
K1 Genes mitocondriales
K1 Modelos Lineales
K1 Mitocondrias
K1 Dióxido de nitrógeno
K1 Placenta
K1 Embarazo
K1 España
AB BACKGROUNDMitochondria are sensitive to environmental toxicants due to their lack of repair capacity. Changes in mitochondrial DNA (mtDNA) content may represent a biologically relevant intermediate outcome in mechanisms linking air pollution and fetal growth restriction.OBJECTIVEWe investigated whether placental mtDNA content is a possible mediator of the association between prenatal nitrogen dioxide (NO2) exposure and birth weight.METHODSWe used data from two independent European cohorts: INMA (n = 376; Spain) and ENVIRONAGE (n = 550; Belgium). Relative placental mtDNA content was determined as the ratio of two mitochondrial genes (MT-ND1 and MTF3212/R3319) to two control genes (RPLP0 and ACTB). Effect estimates for individual cohorts and the pooled data set were calculated using multiple linear regression and mixed models. We also performed a mediation analysis.RESULTSPooled estimates indicated that a 10-μg/m3 increment in average NO2 exposure during pregnancy was associated with a 4.9% decrease in placental mtDNA content (95% CI: -9.3, -0.3%) and a 48-g decrease (95% CI: -87, -9 g) in birth weight. However, the association with birth weight was significant for INMA (-66 g; 95% CI: -111, -23 g) but not for ENVIRONAGE (-20 g; 95% CI: -101, 62 g). Placental mtDNA content was associated with significantly higher mean birth weight (pooled analysis, interquartile range increase: 140 g; 95% CI: 43, 237 g). Mediation analysis estimates, which were derived for the INMA cohort only, suggested that 10% (95% CI: 6.6, 13.0 g) of the association between prenatal NO2 and birth weight was mediated by changes in placental mtDNA content.CONCLUSIONOur results suggest that mtDNA content can be one of the potential mediators of the association between prenatal air pollution exposure and birth weight.CITATIONClemente DB, Casas M, Vilahur N, Begiristain H, Bustamante M, Carsin AE, Fernández MF, Fierens F, Gyselaers W, Iñiguez C, Janssen BG, Lefebvre W, Llop S, Olea N, Pedersen M, Pieters N, Santa Marina L, Souto A, Tardón A, Vanpoucke C, Vrijheid M, Sunyer J, Nawrot TS. 2016. Prenatal ambient air pollution, placental mitochondrial DNA content, and birth weight in the INMA (Spain) and ENVIRONAGE (Belgium) birth cohorts. Environ Health Perspect 124:659-665; http://dx.doi.org/10.1289/ehp.1408981.
PB National Institute of Environmental Health Sciences (NIEHS)
SN 0091-6765
YR 2016
FD 2016-05
LK http://hdl.handle.net/10668/2555
UL http://hdl.handle.net/10668/2555
LA en
NO Clemente DB, Casas M, Vilahur N, Begiristain H, Bustamante M, Carsin AE, et al. Prenatal Ambient Air Pollution, Placental Mitochondrial DNA Content, and Birth Weight in the INMA (Spain) and ENVIRONAGE (Belgium) Birth Cohorts. Environ. Health Perspect. 2016; 124(5):659-65
NO Journal Article;
DS RISalud
RD Apr 18, 2025