RT Journal Article
T1 Predicting Outcomes in Pediatric Ulcerative Colitis for Management Optimization: Systematic Review and Consensus Statements From the Pediatric Inflammatory Bowel Disease-Ahead Program.
A1 Orlanski-Meyer, Esther
A1 Aardoom, Martine
A1 Ricciuto, Amanda
A1 Navon, Dan
A1 Carman, Nicholas
A1 Aloi, Marina
A1 Bronsky, Jiri
A1 Däbritz, Jan
A1 Dubinsky, Marla
A1 Hussey, Séamus
A1 Lewindon, Peter
A1 Martin De Carpi, Javier
A1 Navas-López, Víctor Manuel
A1 Orsi, Marina
A1 Ruemmele, Frank M
A1 Russell, Richard K
A1 Veres, Gabor
A1 Walters, Thomas D
A1 Wilson, David C
A1 Kaiser, Thomas
A1 de Ridder, Lissy
A1 Griffiths, Anne
A1 Turner, Dan
K1 Acute Severe Colitis
K1 Cancer
K1 Colectomy
K1 Mortality
K1 Pediatric Ulcerative Colitis
K1 Prediction
K1 Prognostic Factors
AB A better understanding of prognostic factors in ulcerative colitis (UC) could improve patient management and reduce complications. We aimed to identify evidence-based predictors for outcomes in pediatric UC, which may be used to optimize treatment algorithms. Potential outcomes worthy of prediction in UC were determined by surveying 202 experts in pediatric UC. A systematic review of the literature, with selected meta-analysis, was performed to identify studies that investigated predictors for these outcomes. Multiple national and international meetings were held to reach consensus on evidence-based statements. Consensus was reached on 31 statements regarding predictors of colectomy, acute severe colitis (ASC), chronically active pediatric UC, cancer and mortality. At diagnosis, disease extent (6 studies, N = 627; P = .035), Pediatric Ulcerative Colitis Activity Index score (4 studies, n = 318; P 10 years), male sex, and younger age at diagnosis. These evidence-based consensus statements offer predictions to be considered for a personalized medicine approach in treating pediatric UC.
YR 2020
FD 2020-09-23
LK http://hdl.handle.net/10668/16316
UL http://hdl.handle.net/10668/16316
LA en
DS RISalud
RD Apr 20, 2025