RT Journal Article
T1 Genes Involved in Immune Reinduction May Constitute Biomarkers of Response for Metastatic Melanoma Patients Treated with Targeted Therapy.
A1 Berciano-Guerrero, Miguel-Angel
A1 Lavado-Valenzuela, Rocio
A1 Moya, Aurelio
A1 de-la-Cruz-Merino, Luis
A1 Toscano, Fatima
A1 Valdivia, Javier
A1 Castellon, Victoria
A1 Henao-Carrasco, Fernando
A1 Sancho, Pilar
A1 Onieva-Zafra, Juan-Luis
A1 Navas-Delgado, Ismael
A1 Rueda-Dominguez, Antonio
A1 Perez-Ruiz, Elisabeth
A1 Alba, Emilio
K1 Biomarker
K1 Immunology
K1 Melanoma
K1 Targeted therapy
AB Targeted therapy in metastatic melanoma often achieves a major tumour regression response and significant long-term survival via the release of antigens that reinduce immunocompetence. The biomarkers thus activated may guide the prediction of response, but this association and its mechanism have yet to be established. Blood samples were collected from nineteen consecutive patients with metastatic melanoma before, during, and after treatment with targeted therapy. Differential gene expression analysis was performed, which identified the genes involved in the treatment, both in the first evaluation of response and during progression. Although clinical characteristics of the patients were poorer than those obtained in pivotal studies, radiological responses were similar to those reported previously (objective response rate: 73.7%). In the first tumour assessment, the expression of some genes increased (CXCL-10, SERPING1, PDL1, and PDL2), while that of others decreased (ARG1, IL18R1, IL18RAP, IL1R1, ILR2, FLT3, SLC11A1, CD163, and S100A12). The analysis of gene expression in blood shows that some are activated and others inhibited by targeted therapy. This response pattern may provide biomarkers of the immune reinduction response, which could be used to study potential combination treatments. Nevertheless, further studies are needed to validate these results.
PB MDPI
SN 2227-9059
YR 2022
FD 2022-01-26
LK http://hdl.handle.net/10668/20815
UL http://hdl.handle.net/10668/20815
LA en
NO Berciano-Guerrero MA, Lavado-Valenzuela R, Moya A, delaCruz-Merino L, Toscano F, Valdivia J, et al. Genes Involved in Immune Reinduction May Constitute Biomarkers of Response for Metastatic Melanoma Patients Treated with Targeted Therapy. Biomedicines. 2022 Jan 26;10(2):284.
DS RISalud
RD Apr 7, 2025