TY - JOUR AU - Phillips, Helen M AU - Papoutsi, Tania AU - Soenen, Helena AU - Ybot-Gonzalez, Patricia AU - Henderson, Deborah J AU - Chaudhry, Bill PY - 2012 DO - 10.1371/journal.pone.0037685 UR - http://hdl.handle.net/10668/830 T2 - PloS One AB - Neural crest cells (NCC) give rise to much of the tissue that forms the vertebrate head and face, including cartilage and bone, cranial ganglia and teeth. In this study we show that conditional expression of a dominant-negative (DN) form of Rho kinase... LA - en PB - Public Library of Science KW - Cresta Neural KW - Quinasas Asociadas a rho KW - Apoptosis KW - Actinas KW - Medical Subject Headings::Organisms::Eukaryota::Animals KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis KW - Medical Subject Headings::Anatomy::Embryonic Structures::Branchial Region KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Survival KW - Medical Subject Headings::Diseases::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Congenital Abnormalities KW - Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Cytoskeleton KW - Medical Subject Headings::Anatomy::Body Regions::Head::Face KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic KW - Medical Subject Headings::Anatomy::Embryonic Structures::Neural Crest KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::rho-Associated Kinases KW - Medical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::Biopolymers::Microfilament Proteins::Actins TI - Neural crest cell survival is dependent on Rho kinase and is required for development of the mid face in mouse embryos. TY - research article ER -