RT Journal Article
T1 Impact of high-flow oxygen therapy during exercise in idiopathic pulmonary fibrosis: a pilot crossover clinical trial.
A1 Badenes-Bonet, Diana
A1 Cejudo, Pilar
A1 Rodó-Pin, Anna
A1 Martín-Ontiyuelo, Clara
A1 Chalela, Roberto
A1 Rodríguez-Portal, Jose Antonio
A1 Vázquez-Sánchez, Rosa
A1 Gea, Joaquim
A1 Duran, Xavier
A1 Caguana, Oswaldo Antonio
A1 Rodriguez-Chiaradia, Diego Agustín
A1 Balcells, Eva
K1 Exertional desaturation
K1 High-flow nasal cannula
K1 Idiopathic pulmonary fibrosis
K1 Oxygen therapy
AB Supplemental oxygen delivered with standard oxygen therapy (SOT) improves exercise capacity in patients with idiopathic pulmonary fibrosis (IPF). Although high-flow nasal cannula oxygen therapy (HFNC) improves oxygenation in other respiratory diseases, its impact on exercise performance has never been evaluated in IPF patients. We hypothesized that HFNC may improve exercise capacity in IPF subjects compared to SOT. This was a prospective, crossover, pilot randomized trial that compared both oxygenation methods during a constant submaximal cardiopulmonary exercise test (CPET) in IPF patients with exertional oxygen saturation (SpO2) ≤ 85% in the 6-min walking test. The primary outcome was endurance time (Tlim). Secondary outcomes were muscle oxygen saturation (StO2) and respiratory and leg symptoms. Ten IPF patients [71.7 (6) years old, 90% males] were included. FVC and DLCO were 58 ± 11% and 31 ± 13% pred. respectively. Tlim during CPET was significantly greater using HFNC compared to SOT [494 ± 173 vs. 381 ± 137 s, p = 0.01]. HFNC also associated with a higher increase in inspiratory capacity (IC) [19.4 ± 14.2 vs. 7.1 ± 8.9%, respectively; p = 0.04], and a similar trend was observed in StO2 during exercise. No differences were found in respiratory or leg symptoms between the two oxygen devices. This is the first study demonstrating that HFNC oxygen therapy improves exercise tolerance better than SOT in IPF patients with exertional desaturation. This might be explained by changes in ventilatory mechanics and muscle oxygenation. Further and larger studies are needed to confirm the benefits of HFNC in IPF patients and its potential usefulness in rehabilitation programs.
YR 2021
FD 2021-11-08
LK https://hdl.handle.net/10668/25454
UL https://hdl.handle.net/10668/25454
LA en
DS RISalud
RD Apr 7, 2025