RT Generic
T1 Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma
A1 Manzano-Moreno, Francisco Javier
A1 Costela-Ruiz, Victor J.
A1 Garcia-Recio, Enrique
A1 Olmedo-Gaya, Maria Victoria
A1 Ruiz, Concepcion
A1 Reyes-Botella, Candelaria
K1 salivary biomarker
K1 microRNA
K1 cytokines
K1 oral pathology
K1 diagnosis
K1 oral cancer
K1 Tumor-necrosis-factor
K1 Oxidative stress
K1 Lichen-planus
K1 Immunosuppressive cytokines
K1 Potential biomarkers
K1 Exosomal micrornas
K1 Factor-alpha
K1 Dna-damage
K1 Cancer
K1 Head
AB Oral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among other factors that can serve as biomarkers. Hence, the analysis of saliva may provide useful information for the early diagnosis of OSCC for its prognosis. The objective of this review was to determine the potential usefulness of salivary biomarkers (cytokines and microRNA) to diagnose OSCC and improve its prognosis. A combination of salivary miRNA and proteomic data could allow a definitive and early diagnosis to be obtained. However, there remains a need to optimize and standardize the protocols used to quantify miRNAs.
PB Mdpi
YR 2021
FD 2021-11-01
LK https://hdl.handle.net/10668/28055
UL https://hdl.handle.net/10668/28055
LA en
DS RISalud
RD Apr 6, 2025