RT Journal Article
T1 Genetic markers of lipid metabolism genes associated with low susceptibility to HCV infection.
A1 Real, Luis Miguel
A1 Macias, Juan
A1 Rivero-Juarez, Antonio
A1 Tellez, Francisco
A1 Merino, Dolores
A1 Moreno-Grau, Sonia
A1 Orellana, Adelina
A1 Gomez-Salgado, Juan
A1 Saez, Maria E
A1 Frias, Mario
A1 Corma-Gomez, Anaïs
A1 Merchante, Nicolas
A1 Ruiz, Agustin
A1 Caruz, Antonio
A1 Pineda, Juan A
AB Due to the relation between lipids and Hepatitis C virus (HCV) life-cycle, we aimed to explore the existence of single nucleotide polymorphisms (SNPs) associated with low susceptibility to HCV-infection within lipid metabolism genes. This was a case-control study in three phases: (I) allelic frequencies of 9 SNPs within 6 genes were compared in 404 HCV-infected patients and 801 population controls; (II) results were validated in 602 HCV-infected individuals and 1352 controls; (III) results were confirmed in 30 HCV-exposed uninfected (EU) individuals. In phase I, only the LDLRAP1-rs4075184-A allele was differentially distributed in patients and controls (358 of 808 alleles [44.3%] and 807 of 1602 alleles [50.3%], respectively) (p = 0.004). In phase II, the A allele frequency was 547 of 1204 alleles (45.4%) in patients and 1326 of 2704 alleles (49.0%) in controls (p = 0.037). This frequency in EU was 36 of 60 alleles (60%), which was higher than that observed in patients from phase I (p = 0.018) and phase II (p = 0.027). The LDLRAP1-mRNA expression was lower in AA carriers than in non-AA carriers (median [Q1-Q3]: 0.85 [0.17-1.75] relative-units [ru] versus 1.71 [1.00-2.73] ru; p = 0.041). Our results suggest that LDLRAP1-rs4075184-A allele is associated with lower susceptibility to HCV-infection and with reduced expression of LDLRAP1-mRNA.
YR 2019
FD 2019-06-04
LK http://hdl.handle.net/10668/14156
UL http://hdl.handle.net/10668/14156
LA en
NO Real LM, Macías J, Rivero-Juárez A, Téllez F, Merino D, Moreno-Grau S, et al. Genetic markers of lipid metabolism genes associated with low susceptibility to HCV infection. Sci Rep. 2019 Jun 21;9(1):9054
NO We would like to thank Elisabet Pérez, Paola Micaela Ozzano and Maria Jesús Alvarez-Ossorio for technical assistance. Professor Manuel Serrano Rios, is acknowledged for recruiting individuals representative of the Spanish population that constituted the control group I. This work was supported by grants from the Consejería de Salud de la Junta de Andalucía (PI-001/2017), the Grupo de Estudio de Hepatitis Víricas from the Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (GEHEP-SEIMC) (GEHEP-012), the Plan Nacional de I+ D+ I cofnanced by ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER) (www.red.es/redes/inicio) (RD16/0025/0040, RD12/0017/0012), the AcciónEstratégica en Salud, integrated in the Spanish National R+D+I Plan and fnanced by ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER- “Una manera de Hacer Europa”)(PI13/02434 and PI16/01861), the Ministerio de Economía Industria y Competitividad (SAF2016–8015-R), Fundación Bancaria “La Caixa” and Grifols SA (GR@ACE project). LMR and JM are the recipients of grants fromthe Servicio Andaluz de Salud de la Junta de Andalucía (C-0009-2015 and B-0037, respectively). JAP has received a research extension grant from the Programa de Intensifcación de la Actividad de Investigación del ServicioNacional de Salud Carlos III (I3SNS). Te funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.
DS RISalud
RD Apr 7, 2025