%0 Journal Article
%A Domínguez, Angela
%A Soldevila, Núria
%A Toledo, Diana
%A Godoy, Pere
%A Espejo, Elena
%A Fernandez, Maria Amelia
%A Mayoral, José María
%A Castilla, Jesús
%A Egurrola, Mikel
%A Tamames, Sonia
%A Astray, Jenaro
%A Morales-Suárez-Varela, María
%A The Working Group Of The Project Pi/
%T The effectiveness of influenza vaccination in preventing hospitalisations of elderly individuals in two influenza seasons: a multicentre case-control study, Spain, 2013/14 and 2014/15.
%D 2017
%U http://hdl.handle.net/10668/11546
%X Influenza vaccination may limit the impact of influenza in the community. The aim of this study was to assess the effectiveness of influenza vaccination in preventing hospitalisation in individuals aged ≥ 65 years in Spain. A multicentre case-control study was conducted in 20 Spanish hospitals during 2013/14 and 2014/15. Patients aged ≥ 65 years who were hospitalised with laboratory-confirmed influenza were matched with controls according to sex, age and date of hospitalisation. Adjusted vaccine effectiveness (VE) was calculated by multivariate conditional logistic regression. A total of 728 cases and 1,826 matched controls were included in the study. Overall VE was 36% (95% confidence interval (CI): 22-47). VE was 51% (95% CI: 15-71) in patients without high-risk medical conditions and 30% (95% CI: 14-44) in patients with them. VE was 39% (95% CI: 20-53) in patients aged 65-79 years and 34% (95% CI: 11-51) in patients aged ≥ 80 years, and was greater against the influenza A(H1N1)pdm09 subtype than the A(H3N2) subtype. Influenza vaccination was effective in preventing hospitalisations of elderly individuals.
%K effectiveness
%K elderly
%K hospitalised cases, hospitalised controls
%K influenza
%K matched case–control
%K vaccination
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