RT Journal Article
T1 Influence of age, body mass index and comorbidity on major outcomes in acute pancreatitis, a prospective nation-wide multicentre study.
A1 Moran, Robert A
A1 García-Rayado, Guillermo
A1 de la Iglesia-García, Daniel
A1 Martínez-Moneo, Emma
A1 Fort-Martorell, Esther
A1 Lauret-Braña, Eugenia
A1 Concepción-Martín, Mar
A1 Ausania, Fabio
A1 Prieto-Martínez, Carlos
A1 González-de-Cabo, Miguel
A1 Quesada-Vázquez, Noé
A1 Marcaide-Ruiz-de-Apodaca, M Asunción
A1 Pajares-Díaz, José A
A1 Díaz, Francia C
A1 de-Benito, José L
A1 Hinojosa-Guadix, Jennifer
A1 Marqués-García, Pilar
A1 Boadas, Jaume
A1 Bajador-Andreu, Eduardo
A1 Moreno, Oswaldo
A1 Argüelles-Arias, Federico
A1 Martín-Benítez, Gregorio
A1 Tafur-Sánchez, Carla
A1 Leal-Téllez, Jesús
A1 Romero-Mosquera, Beatriz
A1 Hernaez, Ruben
A1 Papachristou, Georgios I
A1 Singh, Vikesh K
A1 de-Madaria, Enrique
K1 Acute pancreatitis
K1 comorbidities
K1 comorbidity
K1 morbidity
K1 mortality
K1 organ failure
AB There are few large prospective cohort studies evaluating predictors of outcomes in acute pancreatitis. The purpose of this study was to determine the role of age and co-morbid disease in predicting major outcomes in acute pancreatitis. Data points were collected according to a predefined electronic data collection form. Acute pancreatitis and its complications were defined according to the revised Atlanta classification. Univariable and multivariable analyses were conducted using Cox proportional hazard regression and multiple logistic regression. From June 2013-February 2015, 1655 adult patients were recruited from 23 centres across Spain. Co-morbid disease, obesity, open surgical necrosectomy within 30 days, and pancreatic necrosis were independently associated with both 30-day mortality and persistent organ failure (p 85 years) was associated with mortality (p  0.05). Comorbidity and obesity are important determinates of mortality and persistent organ failure in acute pancreatitis, but in the absence of organ failure they do not appear to independently contribute to morbidity. This has important implications for severity classification and predictive models of severity in acute pancreatitis.
SN 2050-6406
YR 2018
FD 2018-09-03
LK https://hdl.handle.net/10668/27722
UL https://hdl.handle.net/10668/27722
LA en
DS RISalud
RD Apr 6, 2025