RT Journal Article
T1 Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study.
A1 Gutiérrez-Bedmar, Mario
A1 Gil, Fernando
A1 Olmedo, Pablo
A1 Ruiz-Canela, Miguel
A1 Martínez-González, Miguel Ángel
A1 Salas-Salvadó, Jordi
A1 Babio, Nancy
A1 Fitó, Montserrat
A1 Del Val García, Jose Luís
A1 Corella, Dolores
A1 Sorlí, José V
A1 Ros, Emilio
A1 Fiol, Miquel
A1 Estruch, Ramón
A1 Santos-Lozano, José Manuel
A1 Arós, Fernando
A1 Serra-Majem, Lluís
A1 Pintó, Xavier
A1 Gómez-Gracia, Enrique
A1 Muñoz-Bravo, Carlos
K1 PREDIMED
K1 cardiovascular disease
K1 mediterranean diet
K1 older populations
K1 serum selenium
AB Background: Selenium is an essential trace mineral with potential interest for cardiovascular disease (CVD) prevention owing to its antioxidant properties. Epidemiological data on selenium status and CVD remain inconsistent. The objective of this study was to ascertain whether low serum selenium (SSe) concentrations are related to an increased risk of a first CVD event in a population at high cardiovascular risk. Methods: We undertook a case-control study nested within the “PREvención con DIeta MEDiterránea” (PREDIMED) trial. A total of 207 participants diagnosed with CVD (myocardial infarction, stroke, or cardiovascular death) during the follow-up period (2003−2010) were matched by sex, age, and intervention group to 436 controls by incidence density sampling. Median time between serum sample collection and subsequent CVD event occurrence was 0.94 years. SSe levels were determined using inductively coupled plasma mass spectrometry analysis. Covariates were assessed through validated questionnaires, in-person interviews, and medical record reviews. Conditional logistic regression was used to calculate multivariable-adjusted odds ratios (ORs). Results: Among women, the mean SSe concentration was lower in cases than in controls (98.5 μg/L vs. 103.8 μg/L; p = 0.016). In controls, SSe levels were directly associated with percentage of total energy intake from proteins and fish intake (p for linear trend
SN 2077-0383
YR 2022
FD 2022-11-10
LK http://hdl.handle.net/10668/21362
UL http://hdl.handle.net/10668/21362
LA en
DS RISalud
RD Apr 17, 2025