TY  - JOUR
AU  - Wenes, Mathias
AU  - Jaccard, Alison
AU  - Wyss, Tania
AU  - Maldonado-Pérez, Noelia
AU  - Teoh, Shao Thing
AU  - Lepez, Anouk
AU  - Renaud, Fabrice
AU  - Franco, Fabien
AU  - Waridel, Patrice
AU  - Yacoub Maroun, Céline
AU  - Tschumi, Benjamin
AU  - Dumauthioz, Nina
AU  - Zhang, Lianjun
AU  - Donda, Alena
AU  - Martín, Francisco
AU  - Migliorini, Denis
AU  - Lunt, Sophia Y
AU  - Ho, Ping-Chih
AU  - Romero, Pedro
PY  - 2022
DO  - 10.1016/j.cmet.2022.03.013
UR  - http://hdl.handle.net/10668/22118
T2  - Cell metabolism
AB  - Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8+ T cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled by the mitochondrial pyruvate carrier (MPC) impact T cell function...
LA  - en
KW  - T cell memory
KW  - chimeric antigen receptor T cell therapy
KW  - immunometabolism
KW  - mitochondrial pyruvate carrier
KW  - tumor-infiltrating lymphocyte metabolism
KW  - Lactates
KW  - Memory T Cells
KW  - Mitochondria
KW  - Mitochondrial Membrane Transport Proteins
KW  - Monocarboxylic Acid Transporters
KW  - Pyruvic Acid
TI  - The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function.
TY  - research article
VL  - 34
ER  -