TY  - JOUR
AU  - Juaristi, Inés
AU  - García-Martín, María L
AU  - Rodrigues, Tiago B
AU  - Satrústegui, Jorgina
AU  - Llorente-Folch, Irene
AU  - Pardo, Beatriz
PY  - 2017
DO  - 10.1111/jnc.14047
UR  - http://hdl.handle.net/10668/11123
T2  - Journal of neurochemistry
AB  - ARALAR/AGC1 (aspartate-glutamate mitochondrial carrier 1) is an important component of the NADH malate-aspartate shuttle (MAS). AGC1-deficiency is a rare disease causing global cerebral hypomyelination, developmental arrest, hypotonia, and epilepsy...
LA  - en
KW  - ARALAR/AGC1 deficiency
KW  - lactate
KW  - magnetic resonance spectroscopy
KW  - malate-aspartate shuttle
KW  - mitochondrial aspartate-glutamate carrier
KW  - mitochondrial disorders
KW  - Aggrecans
KW  - Amino Acid Transport Systems, Acidic
KW  - Animals
KW  - Antiporters
KW  - Astrocytes
KW  - Brain Chemistry
KW  - Glucose
KW  - Glucosephosphate Dehydrogenase
KW  - Hereditary Central Nervous System Demyelinating Diseases
KW  - Lactic Acid
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Mitochondria
KW  - Mitochondrial Diseases
KW  - Nervous System Diseases
KW  - Neurons
KW  - Oxygen Consumption
KW  - Psychomotor Disorders
TI  - ARALAR/AGC1 deficiency, a neurodevelopmental disorder with severe impairment of neuronal mitochondrial respiration, does not produce a primary increase in brain lactate.
TY  - research article
VL  - 142
ER  -