RT Journal Article
T1 Protective Role of Nrf2 in Renal Disease.
A1 Guerrero-Hue, Melania
A1 Rayego-Mateos, Sandra
A1 Vázquez-Carballo, Cristina
A1 Palomino-Antolín, Alejandra
A1 García-Caballero, Cristina
A1 Opazo-Rios, Lucas
A1 Morgado-Pascual, José Luis
A1 Herencia, Carmen
A1 Mas, Sebastián
A1 Ortiz, Alberto
A1 Rubio-Navarro, Alfonso
A1 Egea, Javier
A1 Villalba, José Manuel
A1 Egido, Jesús
A1 Moreno, Juan Antonio
K1 Nrf2
K1 acute kidney injury
K1 and inflammatory response
K1 oxidative stress
K1 renal disease
AB Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted to become by 2040 the fifth global cause of death. CKD is characterized by increased oxidative stress and chronic inflammation. However, therapies to slow or prevent CKD progression remain an unmet need. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that plays a key role in protection against oxidative stress and regulation of the inflammatory response. Consequently, the use of compounds targeting Nrf2 has generated growing interest for nephrologists. Pre-clinical and clinical studies have demonstrated that Nrf2-inducing strategies prevent CKD progression and protect from acute kidney injury (AKI). In this article, we review current knowledge on the protective mechanisms mediated by Nrf2 against kidney injury, novel therapeutic strategies to induce Nrf2 activation, and the status of ongoing clinical trials targeting Nrf2 in renal diseases.
SN 2076-3921
YR 2020
FD 2020-12-31
LK https://hdl.handle.net/10668/28296
UL https://hdl.handle.net/10668/28296
LA en
DS RISalud
RD Apr 11, 2025