TY  - JOUR
AU  - Garcia-Martin, Elena
AU  - Sanchez-Gomez, Francisco J
AU  - Amo, Gemma
AU  - Garcia-Menaya, Jesus
AU  - Cordobes, Concepcion
AU  - Ayuso, Pedro
AU  - Plaza-Seron, M Carmen
AU  - Blanca, Miguel
AU  - Campo, Paloma
AU  - Esguevillas, Gara
AU  - Pajares, Maria A
AU  - Agundez, Jose A G 
AU  - Perez-Sala, Dolores
PY  - 2018
DO  - 10.1002/humu.23548
UR  - http://hdl.handle.net/10668/12422
T2  - Human mutation
AB  - Asthma and rhinitis are two of the main clinical manifestations of allergy, in which increased reactive oxygen or electrophilic species can play a pathogenic role. Aldose reductase (AKR1B1) is involved in aldehyde detoxification and redox balance....
LA  - en
PB  - Wiley
KW  - Aldose reductase
KW  - Allergy
KW  - Asthma
KW  - Protein levels and stability
KW  - Rhinitis
KW  - Variant
KW  - Aldehyde Reductase
KW  - Asthma
KW  - Genotype
KW  - Humans
KW  - MCF-7 Cells
KW  - Mutation
KW  - Protein Stability
KW  - Rhinitis, Allergic
TI  - Asthma and allergic rhinitis associate with the rs2229542 variant that induces a p.Lys90Glu mutation and compromises AKR1B1 protein levels.
TY  - research article
VL  - 39
ER  -