TY - JOUR AU - Garcia-Guerrero, Estefania AU - Perez-Simon, Jose Antonio AU - Sanchez-Abarca, Luis Ignacio AU - Diaz-Moreno, Irene AU - De-la-Rosa, Miguel A AU - Diaz-Quintana, Antonio PY - 2016 DO - 10.1371/journal.pone.0154219 UR - http://hdl.handle.net/10668/10034 T2 - PloS one AB - Generating the immune response requires the discrimination of peptides presented by the human leukocyte antigen complex (HLA) through the T-cell receptor (TCR). However, how a single amino acid substitution in the antigen bonded to HLA affects the... LA - en PB - Public Library of Science KW - Amino Acid Sequence KW - HLA Antigens KW - Peptides KW - Protein Structure, Secondary KW - Thermodynamics KW - Antigen Presentation KW - Binding Sites KW - Humans KW - Molecular Dynamics Simulation KW - Protein Binding KW - Protein Interaction Domains and Motifs KW - Receptors, Antigen, T-Cell KW - Static Electricity TI - The Dynamics of the Human Leukocyte Antigen Head Domain Modulates Its Recognition by the T-Cell Receptor. TY - research article VL - 11 ER -