TY  - JOUR
AU  - Sanchez, Ricardo
AU  - Ayala, Rosa
AU  - Alonso, Rafael Alberto
AU  - Martínez, María Pilar
AU  - Ribera, Jordi
AU  - García, Olga
AU  - Sanchez-Pina, José
AU  - Mercadal, Santiago
AU  - Montesinos, Pau
AU  - Martino, Rodrigo
AU  - Barba, Pere
AU  - González-Campos, José
AU  - Barrios, Manuel
AU  - Lavilla, Esperanza
AU  - Gil, Cristina
AU  - Bernal, Teresa
AU  - Escoda, Lourdes
AU  - Abella, Eugenia
AU  - Amigo, Ma Luz
AU  - Moreno, Ma José
AU  - Bravo, Pilar
AU  - Guàrdia, Ramón
AU  - Hernández-Rivas, Jesús-María
AU  - García-Guiñón, Antoni
AU  - Piernas, Sonia
AU  - Ribera, José-María
AU  - Martínez-López, Joaquín
PY  - 2017
DO  - 10.1007/s00277-017-3002-1
SN  - 0939-5555
UR  - http://hdl.handle.net/10668/2672
T2  - Annals of Hematology
AB  - We investigated the frequency, predictors, and evolution of acute lymphoblastic leukemia (ALL) in patients with CNS relapse and introduced a novel method for studying BCR-ABL1 protein variants in cDNA from bone marrow (BM) and cerebrospinal fluid...
LA  - en
PB  - Springer Verlag
KW  - Neoplasia
KW  - Acute lymphoblastic leukemia relapse
KW  - Central nervous system
KW  - Mutation analysis
KW  - Humanos
KW  - Mesilato de imatinib
KW  - Mutación
KW  - Leucemia-Linfoma linfoblástico de células precursoras
KW  - Proteínas proto-oncogénicas c-bcr
KW  - Recurrencia
KW  - Médula ósea
KW  - Evolución clonal
KW  - ADN complementario
KW  - Secuenciación de nucleótidos de alto rendimiento
KW  - BCR-ABL1
KW  - Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Bone Marrow
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Clonal Evolution
KW  - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA::DNA, Single-Stranded::DNA, Complementary
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::High-Throughput Nucleotide Sequencing
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Benzamides::Imatinib Mesylate
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Lymphoid::Precursor Cell Lymphoblastic Leukemia-Lymphoma
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Oncogene Proteins::Proto-Oncogene Proteins::Proto-Oncogene Proteins c-bcr
KW  - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrence
TI  - Clinical characteristics of patients with central nervous system relapse in BCR-ABL1-positive acute lymphoblastic leukemia: the importance of characterizing ABL1 mutations in cerebrospinal fluid
TY  - research article
ER  -