%0 Journal Article %A Alten, Rieke %A Mariette, Xavier %A Lorenz, Hanns-Martin %A Nüßlein, Hubert %A Galeazzi, Mauro %A Navarro, Federico %A Chartier, Melanie %A Heitzmann, Julia %A Poncet, Coralie %A Rauch, Christiane %A Le Bars, Manuela %T Predictors of abatacept retention over 2 years in patients with rheumatoid arthritis: results from the real-world ACTION study. %D 2019 %U http://hdl.handle.net/10668/13603 %X Evaluate abatacept retention over 2 years in the AbataCepT In rOutiNe clinical practice (ACTION) study. ACTION was an international, observational study of patients with moderate-to-severe rheumatoid arthritis (RA) who initiated intravenous abatacept. Crude abatacept retention rates over 2 years were estimated using Kaplan-Meier analyses in biologic-naive and -failure patients. Clinically relevant risk factors and significant prognostic factors for retention were evaluated using a Cox proportional hazards multivariable model. Overall, 2350/2364 enrolled patients were evaluable; 673 (28.6%) were biologic naive and 1677 (71.4%) had prior biologic failure (1 biologic, 728/1677 [43.4%]; ≥ 2 biologics, 949/1677 [56.6%]). Abatacept retention rate (95% confidence interval [CI]) at 2 years was 47.9% (45.7, 50.0): 54.5% (50.4, 58.3) for biologic-naive vs 45.2% (42.7, 47.7) for biologic-failure patients (log-rank P  Abatacept initiation as earlier vs later line of therapy in RA may achieve higher 2-year retention rates. RF and anti-CCP seropositivity could predict increased abatacept retention, irrespective of treatment line. NCT02109666. %K Biologic %K Efficacy %K Predictor %K Remission %K Rheumatoid arthritis %~