%0 Journal Article
%A Jager, Kitty J
%A Kramer, Anneke
%A Chesnaye, Nicholas C
%A Couchoud, Cécile
%A Sánchez-Álvarez, J Emilio
%A Garneata, Liliana
%A Collart, Fréderic
%A Hemmelder, Marc H
%A Ambühl, Patrice
%A Kerschbaum, Julia
%A Legeai, Camille
%A Del Pino Y Pino, María Dolores
%A Mircescu, Gabriel
%A Mazzoleni, Lionel
%A Hoekstra, Tiny
%A Winzeler, Rebecca
%A Mayer, Gert
%A Stel, Vianda S
%A Wanner, Christoph
%A Zoccali, Carmine
%A Massy, Ziad A
%T Results from the ERA-EDTA Registry indicate a high mortality due to COVID-19 in dialysis patients and kidney transplant recipients across Europe.
%D 2020
%U http://hdl.handle.net/10668/16321
%X The aim of this study was to investigate 28-day mortality after COVID-19 diagnosis in the European kidney replacement therapy population. In addition, we determined the role of patient characteristics, treatment factors, and country on mortality risk with the use of ERA-EDTA Registry data on patients receiving kidney replacement therapy in Europe from February 1, 2020, to April 30, 2020. Additional data on all patients with a diagnosis of COVID-19 were collected from 7 European countries encompassing 4298 patients. COVID-19-attributable mortality was calculated using propensity score-matched historic control data and after 28 days of follow-up was 20.0% (95% confidence interval 18.7%-21.4%) in 3285 patients receiving dialysis and 19.9% (17.5%-22.5%) in 1013 recipients of a transplant. We identified differences in COVID-19 mortality across countries, and an increased mortality risk in older patients receiving kidney replacement therapy and male patients receiving dialysis. In recipients of kidney transplants ≥75 years of age, 44.3% (35.7%-53.9%) did not survive COVID-19. Mortality risk was 1.28 (1.02-1.60) times higher in transplant recipients compared with matched dialysis patients. Thus, the pandemic has had a substantial effect on mortality in patients receiving kidney replacement therapy, a highly vulnerable population due to underlying chronic kidney disease and a high prevalence of multimorbidity.
%K COVID-19
%K attributable mortality
%K dialysis
%K kidney replacement therapy
%K registries
%K transplantation
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