RT Journal Article
T1 Medium to long-term efficacy and safety of oral tacrolimus in moderate to severe steroid refractory ulcerative colitis.
A1 Olmedo-Martin, Raul Vicente
A1 Amo-Trillo, Victor
A1 Gonzalez-Grande, Rocio
A1 Jimenez-Perez, Miguel
K1 Ulcerative colitis
K1 Tacrolimus
K1 Treatment Outcome
K1 Young Adult
AB Oral tacrolimus is an effective drug that induces clinical remission in patients with moderate to severe ulcerative colitis refractory to steroids. However, there is little data with regard to its medium to long-term efficacy and safety. The aim of this study was to assess the medium to long-term efficacy and safety of oral tacrolimus in this challenging clinical situation. This was a retrospective observational review of the clinical charts of 34 patients with moderate to severe ulcerative colitis refractory to steroids treated with oral tacrolimus at our hospital (July 2001-July 2016). Remission was defined as a Lichtiger index score  Seven patients (20.58%) required colectomy during the follow-up period (mean 65 months). Nine patients required rescue with infliximab (four patients during the first six months of follow-up and the other five after the first six months). The short to medium clinical efficacy combining both remission and clinical response was 82% at six months. Kaplan-Meier analysis showed that the percentage of patients free from colectomy and additional sequential rescue therapy was 75% at 54 months (median follow-up). The early introduction of thiopurines (< 2 months from start of tacrolimus) showed no significant improvement in prognosis (p = 0.72). Fifty-three per cent of patients experienced adverse effects, none of whom required treatment withdrawal. No severe infections were noted during the follow-up.
PB Sociedad Española de Patología Digestiva
SN 1130-0108
YR 2017
FD 2017-03-21
LK http://hdl.handle.net/10668/11304
UL http://hdl.handle.net/10668/11304
LA en
NO Olmedo Martín RV, Amo Trillo V, González Grande R, Jiménez Pérez M. Medium to long-term efficacy and safety of oral tacrolimus in moderate to severe steroid refractory ulcerative colitis. Rev Esp Enferm Dig. 2017 Aug;109(8):559-565
DS RISalud
RD Apr 18, 2025