RT Journal Article
T1 Association of Latitude and Exposure to Ultraviolet B Radiation With Severity of Multiple Sclerosis: An International Registry Study.
A1 Vitkova, Marianna
A1 Diouf, Ibrahima
A1 Malpas, Charles
A1 Horakova, Dana
A1 Kubala Havrdova, Eva
A1 Patti, Francesco
A1 Ozakbas, Serkan
A1 Izquierdo, Guillermo
A1 Eichau, Sara
A1 Shaygannejad, Vahid
A1 Onofrj, Marco
A1 Lugaresi, Alessandra
A1 Alroughani, Raed
A1 Prat, Alexandre
A1 Larochelle, Catherine
A1 Girard, Marc
A1 Duquette, Pierre
A1 Terzi, Murat
A1 Boz, Cavit
A1 Grand'Maison, Francois
A1 Sola, Patrizia
A1 Ferraro, Diana
A1 Grammond, Pierre
A1 Butzkueven, Helmut
A1 Buzzard, Katherine
A1 Skibina, Olga
A1 Yamout, Bassem I
A1 Karabudak, Rana
A1 Gerlach, Oliver
A1 Lechner-Scott, Jeannette
A1 Maimone, Davide
A1 Bergamaschi, Roberto
A1 Van Pesch, Vincent
A1 Iuliano, Gerardo
A1 Cartechini, Elisabetta
A1 José Sà, Maria
A1 Ampapa, Radek
A1 Barnett, Michael
A1 Hughes, Stella E
A1 Ramo-Tello, Cristina M
A1 Hodgkinson, Suzanne
A1 Spitaleri, Daniele L A
A1 Petersen, Thor
A1 Butler, Ernest Gerard
A1 Slee, Mark
A1 McGuigan, Chris
A1 McCombe, Pamela Ann
A1 Granella, Franco
A1 Cristiano, Edgardo
A1 Prevost, Julie
A1 Taylor, Bruce V
A1 Sãnchez-Menoyo, Josã Luis
A1 Laureys, Guy
A1 Van Hijfte, Liesbeth
A1 Vucic, Steve
A1 Macdonell, Richard A
A1 Gray, Orla
A1 Olascoaga, Javier
A1 Deri, Norma
A1 Fragoso, Yara Dadalti
A1 Shaw, Cameron
A1 Kalincik, Tomas
A1 MSBase Study Group, 
AB The severity of multiple sclerosis (MS) varies widely among individuals. Understanding the determinants of this heterogeneity will help clinicians optimize the management of MS. The aim of this study was to investigate the association between latitude of residence, UV B radiation (UVB) exposure, and the severity of MS. This observational study used the MSBase registry data. The included patients met the 2005 or 2010 McDonald diagnostic criteria for MS and had a minimum dataset recorded in the registry (date of birth, sex, clinic location, date of MS symptom onset, disease phenotype at baseline and censoring, and ≥1 Expanded Disability Status Scale score recorded). The latitude of each study center and cumulative annualized UVB dose at study center (calculated from National Aeronautics and Space Administration's Total Ozone Mapping Spectrometer) at ages 6 and 18 years and the year of disability assessment were calculated. Disease severity was quantified with Multiple Sclerosis Severity Score (MSSS). Quadratic regression was used to model the associations between latitude, UVB, and MSSS. The 46,128 patients who contributed 453,208 visits and a cumulative follow-up of 351,196 patient-years (70% women, mean age 39.2 ± 12 years, resident between latitudes 19°35' and 56°16') were included in this study. Latitude showed a nonlinear association with MS severity. In latitudes  In temperate zones, MS severity is associated with latitude. This association is mainly, but not exclusively, driven by UVB exposure contributing to both MS susceptibility and severity.
YR 2022
FD 2022-04-11
LK http://hdl.handle.net/10668/20402
UL http://hdl.handle.net/10668/20402
LA en
DS RISalud
RD Apr 8, 2025