RT Journal Article
T1 Diversion Colitis: Macro and Microscopic Findings after Probiotics Stimulation.
A1 Rodríguez-Padilla, Ángela
A1 Morales-Martín, Germán
A1 Pérez-Quintero, Rocío
A1 Gómez-Salgado, Juan
A1 Rada-Morgades, Ricardo
A1 Ruiz-Frutos, Carlos
K1 colonoscopy
K1 diversion colitis
K1 efferent loop stimulation
K1 ileostomy closure
K1 microbiome therapeutics
K1 probiotics
AB The use of a loop ileostomy as the defunctioning procedure of choice to protect a distal colonic anastomosis causes histological and endoscopic changes in the intestinal mucosal architecture, which have been related to chronic inflammation and changes in the microflora that consequently impact the intestinal structure and function following fecal stream diversion. The aim of this study was to evaluate the histological and endoscopic changes on the colonic mucosa in patients with diversion colitis after stimulation of the efferent loop with probiotics prior to closure of the protective ileostomy. A prospective, randomized, double-blind, controlled study was designed. All patients who underwent surgery for colorectal carcinoma with protective ileostomy between January 2017 and December 2018 were included. These patients were pending reconstructive surgery and were diagnosed with endoscopic and histological diversion colitis. Divided into two groups, a group stimulated with probiotics (SG) and a control group (CG). 34 cases and 35 controls were included in the study. Histological and endoscopic changes were evaluated after stimulation, after restorative surgery and during the short-term follow-up after surgery. A decrease in endoscopic pathological findings (mucosal friability, mucous erosions, polyps, edema, erythema and stenosis) and in histological findings (follicular hyperplasia, eosinophils, cryptic abscesses, lymphocyte infiltration, plasma cell infiltration and architecture distortion) was observed in SG. These results were statistically significant with a p
SN 2079-7737
YR 2021
FD 2021-04-06
LK http://hdl.handle.net/10668/17665
UL http://hdl.handle.net/10668/17665
LA en
DS RISalud
RD Apr 7, 2025