TY - JOUR AU - Arbulo-Echevarria, Mikel M AU - Vico-Barranco, Inmaculada AU - Narbona-Sanchez, Isaac AU - Garcia-Cozar, Francisco AU - Miazek, Arkadiusz AU - Aguado, Enrique PY - 2020 DO - 10.3389/fcell.2020.561503 SN - 2296-634X UR - http://hdl.handle.net/10668/16400 T2 - Frontiers in cell and developmental biology AB - The adaptor LAT plays a crucial role in the transduction of signals coming from the TCR/CD3 complex. Phosphorylation of some of its tyrosines generates recruitment sites for other cytosolic signaling molecules. Tyrosine 132 in human LAT is essential... LA - en PB - Frontiers Research Foundation KW - IL-2 (interleukin-2) KW - LAT KW - TCR KW - Anergy KW - Phosphorylation KW - Receptor-CD3 complex, antigen, T-cell KW - Phosphorylation KW - Ligands KW - Peripheral tolerance KW - T-lymphocytes KW - Tyrosine KW - Caspases KW - Glycine TI - Increased Protein Stability and Interleukin-2 Production of a LATG131D Variant With Possible Implications for T Cell Anergy. TY - Research article VL - 8 ER -