RT Journal Article
T1 Signaling pathways involved in colorectal cancer progression
A1 Koveitypour, Zahra
A1 Panahi, Farnoush
A1 Vakilian, Mehrdad
A1 Peymani, Maryam
A1 Seyed Forootan, Farzad
A1 Nasr Esfahani, Mohammad Hossein
A1 Ghaedi, Kamran
K1 Colorectal cancer
K1 EGFR
K1 MAPK
K1 Notch
K1 TGF-B
K1 Neoplasias colorrectales
K1 Genes erbB-1
K1 Proteína quinasa 1 activada por mitógenos
K1 Mitogen-Activated Protein Kinase 1
K1 Receptores Notch
K1 Factor de crecimiento transformador beta
AB Colorectal cancer (CRC) is the fourth leading cause of the worldwide cancer mortality. Different molecular mechanisms have been attributed to the development and progress of CRC. In this review, we will focus on the mitogen-activated protein kinase (MAPK) cascades downstream of the epidermal growth factor receptor (EGFR), Notch, PI3K/AKT pathway, transforming growth factor-β (TGF-β), and Wnt signaling pathways. Various mutations in the components of these signaling pathways have been linked to the development of CRC. Accordingly, numerous efforts have been carried out to target the signaling pathways to develop novel therapeutic approaches. Herein, we review the signaling pathways involved in the incidence and progression of CRC, and the strategies for the therapy targeting components of signaling pathways in CRC.
PB BioMed Central Ltd.
YR 2019
FD 2019-12-02
LK http://hdl.handle.net/10668/3153
UL http://hdl.handle.net/10668/3153
LA en
NO Koveitypour Z, Panahi F, Vakilian M, Peymani M, Seyed Forootan F, Nasr Esfahani MH, et al. Signaling pathways involved in colorectal cancer progression. Cell Biosci. 2019 Dec 2;9:97.
DS RISalud
RD Apr 12, 2025