RT Journal Article
T1 Milk intake and incident stroke and CHD in populations of European descent: a Mendelian randomisation study
A1 Vissers, L. E. T.
A1 Sluijs, I
A1 Burgess, S.
A1 Forouhi, N. G.
A1 Freisling, H.
A1 Imamura, F.
A1 Nilsson, T. K.
A1 Renstroem, F.
A1 Weiderpass, E.
A1 Aleksandrova, K.
A1 Dahm, C. C.
A1 Perez-Cornago, A.
A1 Schulze, M. B.
A1 Tong, T. Y. N.
A1 Aune, D.
A1 Bonet, C.
A1 Boer, J. M. A.
A1 Boeing, H.
A1 Chirlaque, M. D.
A1 Conchi, M., I
A1 Imaz, L.
A1 Jaeger, S.
A1 Krogh, V
A1 Kyro, C.
A1 Masala, G.
A1 Melander, O.
A1 Overvad, K.
A1 Panico, S.
A1 Sanches, M. J.
A1 Sonestedt, E.
A1 Tjonneland, A.
A1 Tzoulaki, I
A1 Verschuren, W. M. M.
A1 Riboli, E.
A1 Wareham, N. J.
A1 Danesh, J.
A1 Butterworth, A. S.
A1 van der Schouw, Y. T.
K1 Milk
K1 Dairy
K1 CHD
K1 Stroke
K1 Mendelian randomisation
K1 Ischemic-heart-disease
K1 Lactase persistence genotype
K1 Blood-pressure response
K1 Prostate-cancer
K1 Life-style
K1 Health
K1 Consumption
K1 Cohort
K1 Risk
K1 Participants
AB Higher milk intake has been associated with a lower stroke risk, but not with risk of CHD. Residual confounding or reverse causation cannot be excluded. Therefore, we estimated the causal association of milk consumption with stroke and CHD risk through instrumental variable (IV) and gene-outcome analyses. IV analysis included 29 328 participants (4611 stroke; 9828 CHD) of the European Prospective Investigation into Cancer and Nutrition (EPIC)-CVD (eight European countries) and European Prospective Investigation into Cancer and Nutrition-Netherlands (EPIC-NL) case-cohort studies. rs4988235, a lactase persistence (LP) SNP which enables digestion of lactose in adulthood was used as genetic instrument. Intake of milk was first regressed on rs4988235 in a linear regression model. Next, associations of genetically predicted milk consumption with stroke and CHD were estimated using Prentice-weighted Cox regression. Gene-outcome analysis included 777 024 participants (50 804 cases) from MEGASTROKE (including EPIC-CVD), UK Biobank and EPIC-NL for stroke, and 483 966 participants (61 612 cases) from CARDIoGRAM, UK Biobank, EPIC-CVD and EPIC-NL for CHD. In IV analyses, each additional LP allele was associated with a higher intake of milk in EPIC-CVD (beta = 13 center dot 7 g/d; 95 % CI 8 center dot 4, 19 center dot 1) and EPIC-NL (36 center dot 8 g/d; 95 % CI 20 center dot 0, 53 center dot 5). Genetically predicted milk intake was not associated with stroke (HR per 25 g/d 1 center dot 05; 95 % CI 0 center dot 94, 1 center dot 16) or CHD (1 center dot 02; 95 % CI 0 center dot 96, 1 center dot 08). In gene-outcome analyses, there was no association of rs4988235 with risk of stroke (OR 1 center dot 02; 95 % CI 0 center dot 99, 1 center dot 05) or CHD (OR 0 center dot 99; 95 % CI 0 center dot 95, 1 center dot 03). Current Mendelian randomisation analysis does not provide evidence for a causal inverse relationship between milk consumption and stroke or CHD risk.
PB Cambridge univ press
SN 0007-1145
YR 2021
FD 2021-10-21
LK https://hdl.handle.net/10668/24652
UL https://hdl.handle.net/10668/24652
LA en
DS RISalud
RD Apr 17, 2025