RT Journal Article
T1 Differential cognitive impairment for diverse forms of multiple sclerosis.
A1 Gonzalez-Rosa, Javier J
A1 Vazquez-Marrufo, Manuel
A1 Vaquero, Encarnacion
A1 Duque, Pablo
A1 Borges, Monica
A1 Gamero, Miguel A
A1 Gomez, Carlos M
A1 Izquierdo, Guillermo
K1 Conducta
K1 Adulto
K1 Trastornos del Conocimiento
K1 Señales
K1 Femenino
K1 Humanos
K1 Masculino
K1 Esclerosis Múltiple
K1 Esclerosis Múltiple Recurrente-Remitente
K1 Electroencefalografía
AB BACKGROUNDCognitive impairment is a common feature in multiple sclerosis (MS) patients and occurs in 60% of all cases. Unfortunately, neurological examination does not always agree with the neuropsychological evaluation in determining the cognitive profile of the patient. On the other hand, psychophysiological techniques such as event-related potentials (ERPs) can help in evaluating cognitive impairment in different pathologies. Behavioural responses and EEG signals were recorded during the experiment in three experimental groups: 1) a relapsing-remitting group (RRMS), 2) a benign multiple sclerosis group (BMS) and 3) a Control group. The paradigm employed was a spatial attention task with central cues (Posner experiment). The main aim was to observe the differences in the performance (behavioural variables) and in the latency and amplitude of the ERP components among these groups.RESULTSOur data indicate that both MS groups showed poorer task performance (longer reaction times and lower percentage of correct responses), a latency delay for the N1 and P300 component, and a different amplitude for the frontal N1. Moreover, the deficit in the BMS group, indexed by behavioural and pyschophysiological variables, was more pronounced compared to the RRMS group.CONCLUSIONThe present results suggest a cognitive impairment in the information processing in all of these patients. Comparing both pathological groups, cognitive impairment was more accentuated in the BMS group compared to the RMSS group. This suggests a silent deterioration of cognitive skills for the BMS that is not usually treated with pharmacological or neuropsychological therapy.
PB BMC
YR 2006
FD 2006-05-19
LK http://hdl.handle.net/10668/817
UL http://hdl.handle.net/10668/817
LA en
NO Gonzalez-Rosa JJ, Vazquez-Marrufo M, Vaquero E, Duque P, Borges M, Gamero MA, et al. Differential cognitive impairment for diverse forms of multiple sclerosis. BMC Neurosci; 2006, 7:39
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 5, 2025