RT Journal Article
T1 Standardized incidence ratios and risk factors for cancer in patients with systemic sclerosis: Data from the Spanish Scleroderma Registry (RESCLE).
A1 Carbonell, Cristina
A1 Marcos, Miguel
A1 Guillen-Del-Castillo, Alfredo
A1 Rubio-Rivas, Manuel
A1 Argibay, Ana
A1 Marin-Ballve, Adela
A1 Rodriguez-Pinto, Ignasi
A1 Balda-Masmiquel, Maria
A1 Callejas-Moraga, Eduardo
A1 Colunga, Dolores
A1 Saez-Comet, Luis
A1 Gonzalez-Echavarri, Cristina
A1 Ortego-Centeno, Norberto
A1 Mari-Alfonso, Begoña
A1 Vargas-Hitos, Jose-Antonio
A1 Todoli-Parra, Jose-Antonio
A1 Trapiella, Luis
A1 Herranz-Marin, Maria-Teresa
A1 Freire, Mayka
A1 Castro-Salomo, Antoni
A1 Perales-Fraile, Isabel
A1 Madroñero-Vuelta, Ana-Belen
A1 Sanchez-Garcia, Maria-Esther
A1 Ruiz-Muñoz, Manuel
A1 Gonzalez-Garcia, Andres
A1 Sanchez-Redondo, Jorge
A1 de-la-Red-Bellvis, Gloria
A1 Fernandez-Luque, Alejandra
A1 Muela-Molinero, Alberto
A1 Lledo, Gema-Maria
A1 Tolosa-Vilella, Carles
A1 Fonollosa-Pla, Vicent
A1 Chamorro, Antonio-Javier
A1 Simeon-Aznar, Carmen-Pilar
K1 Anticentromere antibody
K1 Cancer
K1 Primary biliary cholangitis
K1 Systemic sclerosis
AB Patients with systemic sclerosis (SSc) are at increased risk of cancer, a growing cause of non-SSc-related death among these patients. We analyzed the increased cancer risk among Spanish patients with SSc using standardized incidence ratios (SIRs) and identified independent cancer risk factors in this population. Spanish Scleroderma Registry data were analyzed to determine the demographic characteristics of patients with SSc, and logistic regression was used to identify cancer risk factors. SIRs with 95% confidence intervals (CIs) relative to the general Spanish population were calculated. Of 1930 patients with SSc, 206 had cancer, most commonly breast, lung, hematological, and colorectal cancers. Patients with SSc had increased risks of overall cancer (SIR 1.48, 95% CI 1.36-1.60; P  Spanish patients with SSc had an increased cancer risk compared with the general population. Some characteristics, including specific autoantibodies, may be related to this increased risk.
PB Elsevier Inc.
YR 2022
FD 2022-07-31
LK http://hdl.handle.net/10668/22025
UL http://hdl.handle.net/10668/22025
LA en
NO Carbonell C, Marcos M, Guillén-Del-Castillo A, Rubio-Rivas M, Argibay A, Marín-Ballvé A, et al, Autoimmune Diseases Study Group (GEAS). Standardized incidence ratios and risk factors for cancer in patients with systemic sclerosis: Data from the Spanish Scleroderma Registry (RESCLE). Autoimmun Rev. 2022 Oct;21(10):103167.
NO This work was financed in part by the Autoimmune Diseases StudyGroup of the Spanish Society of Internal Medicine.
DS RISalud
RD Apr 17, 2025