%0 Journal Article
%A Baus-Domínguez, M
%A Gómez-Díaz, R
%A Torres-Lagares, D
%A Corcuera-Flores, J R
%A Ruiz-Villandiego, J C
%A Machuca-Portillo, G
%A Gutiérrez-Pérez, J L
%A Serrera-Figallo, M A
%T Differential Expression of Inflammation-Related Genes in Down Syndrome Patients with or without Periodontal Disease.
%D 2019
%U http://hdl.handle.net/10668/14748
%X Aware that Down Syndrome patients present among their clinical characteristics impaired immunity, the aim of this study is to identify the statistically significant differences in inflammation-related gene expression by comparing Down Syndrome patients with Periodontal Disease (DS+PD+) with Down Syndrome patients without Periodontal Disease (DS+PD-), and their relationship with periodontitis as a chronic oral inflammatory clinical feature. Case study and controls on eleven Down Syndrome patients (DS+PD+ vs. DS+PD-). RNA was extracted from peripheral blood using a Qiagen PAXgene Blood miRNA Kit when performing an oral examination. A search for candidate genes (92 selected) was undertaken on the total genes obtained using a Scientific GeneChip® Scanner 3000 (Thermo Fisher Scientific) and Clariom S solutions for human, mouse, and rat chips, with more than 20,000 genes annotated for measuring expression levels. Of the 92 inflammation-related genes taken initially, four genes showed a differential expression across both groups with a p value of  There are differences in inflammation-related gene expression in Down Syndrome patients when comparing patients who present a state of chronic oral inflammation with patients with negative rates of periodontal disease.
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