RT Journal Article
T1 Reduced Prepulse Inhibition as a Biomarker of Schizophrenia.
A1 Mena, Auxiliadora
A1 Ruiz-Salas, Juan C
A1 Puentes, Andrea
A1 Dorado, Inmaculada
A1 Ruiz-Veguilla, Miguel
A1 De la Casa, Luis G
K1 endophenotype
K1 habituation
K1 prepulse inhibition
K1 schizophrenia
K1 startle
AB The startle response is composed by a set of reflex behaviors intended to prepare the organism to face a potentially relevant stimulus. This response can be modulated by several factors as, for example, repeated presentations of the stimulus (startle habituation), or by previous presentation of a weak stimulus (Prepulse Inhibition [PPI]). Both phenomena appear disrupted in schizophrenia that is thought to reflect an alteration in dopaminergic and glutamatergic neurotransmission. In this paper we analyze whether the reported deficits are indicating a transient effect restricted to the acute phase of the disease, or if it reflects a more general biomarker or endophenotype of the disorder. To this end, we measured startle responses in the same set of thirteen schizophrenia patients with a cross-sectional design at two periods: 5 days after hospital admission and 3 months after discharge. The results showed that both startle habituation and PPI were impaired in the schizophrenia patients at the acute stage as compared to a control group composed by 13 healthy participants, and that PPI but not startle habituation remained disrupted when registered 3 months after the discharge. These data point to the consideration of PPI, but not startle habituation, as a schizophrenia biomarker.
SN 1662-5153
YR 2016
FD 2016-10-18
LK http://hdl.handle.net/10668/10570
UL http://hdl.handle.net/10668/10570
LA en
DS RISalud
RD Apr 5, 2025